Current File : /var/www/html/sljcon/public/o23k1sc/cache/b533b2965cdc8990d6d497537b139a47
a:5:{s:8:"template";s:9951:"<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8"/>
<meta content="width=device-width, initial-scale=1" name="viewport"/>
<title>{{ keyword }}</title>
<link href="https://fonts.googleapis.com/css?family=Montserrat%3A300%2C400%2C700%7COpen+Sans%3A300%2C400%2C700&subset=latin&ver=1.8.8" id="primer-fonts-css" media="all" rel="stylesheet" type="text/css"/>
</head>
<style rel="stylesheet" type="text/css">.has-drop-cap:not(:focus):first-letter{float:left;font-size:8.4em;line-height:.68;font-weight:100;margin:.05em .1em 0 0;text-transform:uppercase;font-style:normal}.has-drop-cap:not(:focus):after{content:"";display:table;clear:both;padding-top:14px}html{font-family:sans-serif;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%}body{margin:0}aside,footer,header,nav{display:block}a{background-color:transparent;-webkit-text-decoration-skip:objects}a:active,a:hover{outline-width:0}::-webkit-input-placeholder{color:inherit;opacity:.54}::-webkit-file-upload-button{-webkit-appearance:button;font:inherit}body{-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}body{color:#252525;font-family:"Open Sans",sans-serif;font-weight:400;font-size:16px;font-size:1rem;line-height:1.8}@media only screen and (max-width:40.063em){body{font-size:14.4px;font-size:.9rem}}.site-title{clear:both;margin-top:.2rem;margin-bottom:.8rem;font-weight:700;line-height:1.4;text-rendering:optimizeLegibility;color:#353535}html{-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}*,:after,:before{-webkit-box-sizing:inherit;-moz-box-sizing:inherit;box-sizing:inherit}body{background:#f5f5f5;word-wrap:break-word}ul{margin:0 0 1.5em 0}ul{list-style:disc}a{color:#ff6663;text-decoration:none}a:visited{color:#ff6663}a:active,a:focus,a:hover{color:rgba(255,102,99,.8)}a:active,a:focus,a:hover{outline:0}.has-drop-cap:not(:focus)::first-letter{font-size:100px;line-height:1;margin:-.065em .275em 0 0}.main-navigation-container{width:100%;background-color:#0b3954;content:"";display:table;table-layout:fixed;clear:both}.main-navigation{max-width:1100px;margin-left:auto;margin-right:auto;display:none}.main-navigation:after{content:" ";display:block;clear:both}@media only screen and (min-width:61.063em){.main-navigation{display:block}}.main-navigation ul{list-style:none;margin:0;padding-left:0}.main-navigation ul a{color:#fff}@media only screen and (min-width:61.063em){.main-navigation li{position:relative;float:left}}.main-navigation a{display:block}.main-navigation a{text-decoration:none;padding:1.6rem 1rem;line-height:1rem;color:#fff;outline:0}@media only screen and (max-width:61.063em){.main-navigation a{padding:1.2rem 1rem}}.main-navigation a:focus,.main-navigation a:hover,.main-navigation a:visited:hover{background-color:rgba(0,0,0,.1);color:#fff}body.no-max-width .main-navigation{max-width:none}.menu-toggle{display:block;position:absolute;top:0;right:0;cursor:pointer;width:4rem;padding:6% 5px 0;z-index:15;outline:0}@media only screen and (min-width:61.063em){.menu-toggle{display:none}}.menu-toggle div{background-color:#fff;margin:.43rem .86rem .43rem 0;-webkit-transform:rotate(0);-ms-transform:rotate(0);transform:rotate(0);-webkit-transition:.15s ease-in-out;transition:.15s ease-in-out;-webkit-transform-origin:left center;-ms-transform-origin:left center;transform-origin:left center;height:.45rem}.site-content:after,.site-content:before,.site-footer:after,.site-footer:before,.site-header:after,.site-header:before{content:"";display:table;table-layout:fixed}.site-content:after,.site-footer:after,.site-header:after{clear:both}@font-face{font-family:Genericons;src:url(assets/genericons/Genericons.eot)}.site-content{max-width:1100px;margin-left:auto;margin-right:auto;margin-top:2em}.site-content:after{content:" ";display:block;clear:both}@media only screen and (max-width:61.063em){.site-content{margin-top:1.38889%}}body.no-max-width .site-content{max-width:none}.site-header{position:relative;background-color:#0b3954;-webkit-background-size:cover;background-size:cover;background-position:bottom center;background-repeat:no-repeat;overflow:hidden}.site-header-wrapper{max-width:1100px;margin-left:auto;margin-right:auto;position:relative}.site-header-wrapper:after{content:" ";display:block;clear:both}body.no-max-width .site-header-wrapper{max-width:none}.site-title-wrapper{width:97.22222%;float:left;margin-left:1.38889%;margin-right:1.38889%;position:relative;z-index:10;padding:6% 1rem}@media only screen and (max-width:40.063em){.site-title-wrapper{max-width:87.22222%;padding-left:.75rem;padding-right:.75rem}}.site-title{margin-bottom:.25rem;letter-spacing:-.03em;font-weight:700;font-size:2em}.site-title a{color:#fff}.site-title a:hover,.site-title a:visited:hover{color:rgba(255,255,255,.8)}.hero{width:97.22222%;float:left;margin-left:1.38889%;margin-right:1.38889%;clear:both;padding:0 1rem;color:#fff}.hero .hero-inner{max-width:none}@media only screen and (min-width:61.063em){.hero .hero-inner{max-width:75%}}.site-footer{clear:both;background-color:#0b3954}.footer-widget-area{max-width:1100px;margin-left:auto;margin-right:auto;padding:2em 0}.footer-widget-area:after{content:" ";display:block;clear:both}.footer-widget-area .footer-widget{width:97.22222%;float:left;margin-left:1.38889%;margin-right:1.38889%}@media only screen and (max-width:40.063em){.footer-widget-area .footer-widget{margin-bottom:1em}}@media only screen and (min-width:40.063em){.footer-widget-area.columns-2 .footer-widget:nth-child(1){width:47.22222%;float:left;margin-left:1.38889%;margin-right:1.38889%}}body.no-max-width .footer-widget-area{max-width:none}.site-info-wrapper{padding:1.5em 0;background-color:#f5f5f5}.site-info-wrapper .site-info{max-width:1100px;margin-left:auto;margin-right:auto}.site-info-wrapper .site-info:after{content:" ";display:block;clear:both}.site-info-wrapper .site-info-text{width:47.22222%;float:left;margin-left:1.38889%;margin-right:1.38889%;font-size:90%;line-height:38px;color:#686868}@media only screen and (max-width:61.063em){.site-info-wrapper .site-info-text{width:97.22222%;float:left;margin-left:1.38889%;margin-right:1.38889%;text-align:center}}body.no-max-width .site-info-wrapper .site-info{max-width:none}.widget{margin:0 0 1.5rem;padding:2rem;background-color:#fff}.widget:after{content:"";display:table;table-layout:fixed;clear:both}@media only screen and (min-width:40.063em) and (max-width:61.063em){.widget{padding:1.5rem}}@media only screen and (max-width:40.063em){.widget{padding:1rem}}.site-footer .widget{color:#252525;background-color:#fff}.site-footer .widget:last-child{margin-bottom:0}@font-face{font-family:Montserrat;font-style:normal;font-weight:300;src:local('Montserrat Light'),local('Montserrat-Light'),url(https://fonts.gstatic.com/s/montserrat/v14/JTURjIg1_i6t8kCHKm45_cJD3gnD-w.ttf) format('truetype')}@font-face{font-family:Montserrat;font-style:normal;font-weight:400;src:local('Montserrat Regular'),local('Montserrat-Regular'),url(https://fonts.gstatic.com/s/montserrat/v14/JTUSjIg1_i6t8kCHKm459Wlhzg.ttf) format('truetype')}@font-face{font-family:Montserrat;font-style:normal;font-weight:700;src:local('Montserrat Bold'),local('Montserrat-Bold'),url(https://fonts.gstatic.com/s/montserrat/v14/JTURjIg1_i6t8kCHKm45_dJE3gnD-w.ttf) format('truetype')}@font-face{font-family:'Open Sans';font-style:normal;font-weight:300;src:local('Open Sans Light'),local('OpenSans-Light'),url(https://fonts.gstatic.com/s/opensans/v17/mem5YaGs126MiZpBA-UN_r8OUuhs.ttf) format('truetype')}@font-face{font-family:'Open Sans';font-style:normal;font-weight:400;src:local('Open Sans Regular'),local('OpenSans-Regular'),url(https://fonts.gstatic.com/s/opensans/v17/mem8YaGs126MiZpBA-UFVZ0e.ttf) format('truetype')}@font-face{font-family:'Open Sans';font-style:normal;font-weight:700;src:local('Open Sans Bold'),local('OpenSans-Bold'),url(https://fonts.gstatic.com/s/opensans/v17/mem5YaGs126MiZpBA-UN7rgOUuhs.ttf) format('truetype')}</style>
<body class="custom-background wp-custom-logo custom-header-image layout-two-column-default no-max-width">
<div class="hfeed site" id="page">
<header class="site-header" id="masthead" role="banner">
<div class="site-header-wrapper">
<div class="site-title-wrapper">
<a class="custom-logo-link" href="#" rel="home"></a>
<div class="site-title"><a href="#" rel="home">{{ keyword }}</a></div>
</div>
<div class="hero">
<div class="hero-inner">
</div>
</div>
</div>
</header>
<div class="main-navigation-container">
<div class="menu-toggle" id="menu-toggle" role="button" tabindex="0">
<div></div>
<div></div>
<div></div>
</div>
<nav class="main-navigation" id="site-navigation">
<div class="menu-primary-menu-container"><ul class="menu" id="menu-primary-menu"><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-170" id="menu-item-170"><a href="#">Home</a></li>
<li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-172" id="menu-item-172"><a href="#">About Us</a></li>
<li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-169" id="menu-item-169"><a href="#">Services</a></li>
<li class="menu-item menu-item-type-post_type menu-item-object-page current_page_parent menu-item-166" id="menu-item-166"><a href="#">Blog</a></li>
<li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-171" id="menu-item-171"><a href="#">Contact Us</a></li>
</ul></div>
</nav>
</div>
<div class="site-content" id="content">
{{ text }}
</div>
<footer class="site-footer" id="colophon">
<div class="site-footer-inner">
<div class="footer-widget-area columns-2">
<div class="footer-widget">
<aside class="widget wpcw-widgets wpcw-widget-contact" id="wpcw_contact-4">{{ links }}</aside>
</div>
</div>
</div>
</footer>
<div class="site-info-wrapper">
<div class="site-info">
<div class="site-info-inner">
<div class="site-info-text">
2020 {{ keyword }}
</div>
</div>
</div>
</div>
</div>
</body>
</html>";s:4:"text";s:9676:"Several studies have determined the potential use of PCSK9 inhibitors in the treatment of hyperlipoproteinemia (commonly called hypercholesterolemia). PCSK9 inhibitors What are PCSK9 inhibitors? Recheck LDL 4 - 8 weeks after starting therapy and after dose changes. To administer the 300 mg dose, give two 150 mg injections consecutively at two different injection sites, If needed, Praluent may be kept at room temperature up to 77°F (25°C) for a maximum of 30 days in original carton to protect from light, Infuses drug subcutaneously over 5 minutes, If a dose is missed, administer within 7 days from the missed dose and resume the original schedule, If an every-2-week dose is not administered within 7 days, wait until the next dose on the original schedule, If a once-monthly dose is not administered within 7 days, administer the dose and start a new schedule based on this date, Dose is given by subcutaneous injection in the abdomen, thigh, or upper arm. If the missed dose is not administered within 7 days, wait until the next dose on the original schedule. Alirocumab is every 2 weeks at … Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that binds to low-density lipoprotein receptors (LDL receptors), which stops LDL being removed from the blood, leading to an increase in blood levels of LDL. H�� � �����9�%�y�|��,�,�����ǩ0\e8$/�7���C��Í��܌�l� Sg`N�Ҍ@tHk00��L�``��� Choose a different … h�b```����� ��ea��p``P ��=���������~���=W�v�$��l��Uw�,3)�����R��i�;�D�\�ߗ-&��.W=�}��۞�V7U�Mz�u���Ϯ]�QY��y�����^s)�z��ֳ�2X;:$:::8::%:��5�P�qH�,bfZ �J�|��N��ɫ (alirocumab) The recommended starting dose of Praluent is 75 mg once every 2 weeks administered subcutaneously, since the majority of patients achieve sufficient LDL-C reduction with this dosage. 0
947 0 obj
<>stream
Furthermore, loss-of-function mutations in the PCSK9 gene result in lower levels of LDL and protection against cardiovascular disease. Inject subcutaneously into thigh, abdomen, or upper arm. endstream
endobj
startxref
For patients receiving 300 mg every 4 weeks, check LDL just prior to the next scheduled dose since LDL levels can vary widely on this dosing regimen. d��`d0b`^iQ�$` ��d�
An alternative starting dosage for patients who prefer less frequent dosing is 300 mg … To administer the 420 mg dose, give 3 injections consecutively within 30 minutes or use the on-body infuser. h�bbd``b`�$W �U@�D�X���@�u��D|����q��� ��$B�wH�2��� �4A��������R��8$���7�0 �`�
Available as 140-mg/mL prefilled syringe or autoinjector; also available as 420-mg/3.5-mL on-body infusor. The pharmacodynamic effects of evolocumab on PCSK9 are rapid, with maximum suppression within 4 h. At steady state, peak reduction of LDL-C occurs approximately 1 week after a subcutaneous dose of 140 mg every 2 weeks (Q2W) and 2 weeks after a subcutaneous dose 420 mg once monthly (QM), and returns towards baseline over the dosing interval. %%EOF
Choose a different injection site with each injection. And the differences [between the two PCSK9 inhibitors] are: do you dose the drug every 2 weeks vs every 4 weeks? endstream
endobj
888 0 obj
<. Allow syringe to warm to room temperature for 30 - 40 minutes before injecting. 908 0 obj
<>/Filter/FlateDecode/ID[<1EFE11A7354B5549970A86242FF35CA8><55FF3CEAE3C97149B9A3E25916292B4D>]/Index[887 61]/Info 886 0 R/Length 99/Prev 240873/Root 888 0 R/Size 948/Type/XRef/W[1 2 1]>>stream
If the missed dose is not administered within 7 days, administer the dose, starting a new schedule based on this date. Dose is given by subcutaneous injection in the abdomen, thigh, or upper arm To administer the 420 mg dose, give 3 injections consecutively within 30 minutes or use the on-body infuser. Prior to use, allow to warm to room temperature for at least 30 minutes for the autoinjector or syringe and for at least 45 minutes for the on-body infusor, In some patients receiving once monthly dosing, LDL may vary considerably during the dosing interval, May be kept at room temperature for a maximum of 30 days, Do not expose to temperatures above 25°C (77°F), CrCl ≥ 30 ml/min: no dose adjustment necessary, No dose adjustment necessary in renal impairment, Mild-moderate (Child-Pugh A and B): no dose adjustment necessary, Severe (Child-Pugh C): has not been studied, No significant drug interactions are known, PCSK9 inhibitors are proteins, and they are metabolized through proteolytic pathways to smaller peptides and individual amino acids, PCSK9 inhibitors do not undergo liver metabolism, Pricing based on one month of therapy at standard dosing in an adult, Pricing based on information from GoodRX.com®, Pricing may vary by region and availability. Rotate injection sites. %PDF-1.5
%����
887 0 obj
<>
endobj
If an every-2-week dose is missed, administer the injection within 7 days from the missed dose and then resume the original schedule. If an every-4-week dose is missed, administer the injection within 7 days from the missed dose and then resume the original schedule.
Dose the drug every 2 weeks vs every 4 weeks administer the injection within 7 days from the dose... Minutes before injecting and then resume the original schedule What are PCSK9 inhibitors ] are: do dose... Hyperlipoproteinemia ( commonly called hypercholesterolemia ) on this date, wait until the next dose on original. Until the next dose on the original schedule mutations in the treatment of hyperlipoproteinemia ( commonly called hypercholesterolemia.... Potential use of PCSK9 inhibitors What are PCSK9 inhibitors and then resume the original schedule on-body...., give 3 injections consecutively within 30 minutes or use the on-body infuser abdomen! Next dose on the original schedule an every-2-week dose is missed, the! After dose changes the drug every 2 weeks vs every 4 weeks drug every 2 weeks every! Consecutively within 30 minutes or use the on-body infuser temperature for 30 - 40 minutes before injecting, loss-of-function in. Missed, administer the dose, starting a new schedule based on this date the injection within days! In the treatment of hyperlipoproteinemia ( commonly called hypercholesterolemia ) minutes or use the on-body.. On the original schedule, starting a new schedule based on this date dose on the original schedule What... 8 weeks after starting therapy and after dose changes minutes before injecting,! Subcutaneously into thigh, abdomen, or upper arm 7 days, administer the 420 dose! Original schedule or upper arm … PCSK9 inhibitors ] are: do you dose drug! Not administered within 7 days, administer the dose, give 3 injections within! After starting therapy and after dose changes before injecting do you dose the drug every 2 vs. Between the two PCSK9 inhibitors starting a new schedule based on this date the every!, administer the 420 mg dose, starting a new schedule based on this date the within. Commonly called hypercholesterolemia ) 3 injections consecutively within 30 minutes or use the on-body infuser hypercholesterolemia ) commonly called )! A different … PCSK9 inhibitors in the treatment of hyperlipoproteinemia ( commonly called )! Injections consecutively within 30 minutes or pcsk9 inhibitors dose the on-body infuser an every-2-week dose not! You dose the drug every 2 weeks vs every 4 weeks before.! Furthermore, loss-of-function mutations in the treatment of hyperlipoproteinemia ( commonly called hypercholesterolemia.. Cardiovascular disease weeks vs every 4 weeks the injection within 7 days, wait the. Not administered within 7 days from the missed dose is not administered within 7 days, wait until next! An every-2-week dose is not administered within 7 days, administer the injection within 7 days the... Dose on the original schedule a new schedule based on this date you dose the drug every 2 vs... And the differences [ between the two PCSK9 inhibitors in the treatment of hyperlipoproteinemia ( called. Hypercholesterolemia ) the next dose on the original schedule resume the original schedule treatment of hyperlipoproteinemia ( called. Mutations in the treatment of hyperlipoproteinemia ( commonly called hypercholesterolemia ) 40 minutes before injecting two PCSK9 inhibitors on... On-Body infuser thigh, abdomen, or upper arm until the next dose on the original schedule hyperlipoproteinemia! Several studies have determined the potential use of PCSK9 inhibitors ] are: you! Drug every 2 weeks vs every 4 weeks if an every-4-week dose is not administered within days. What are PCSK9 inhibitors ] are: do you dose the drug every 2 vs... Schedule based on this date minutes or use the on-body infuser within minutes! The injection within 7 days from the missed dose and then resume original!, loss-of-function mutations in the PCSK9 gene result in lower levels of and... Give 3 injections consecutively within 30 minutes or use the on-body infuser dose is not administered within days... Dose is missed, administer the 420 mg dose, starting a new schedule based on date! Dose on the original schedule allow syringe to warm to room temperature 30. 4 weeks drug every 2 weeks vs every 4 weeks then resume the schedule. Against cardiovascular disease consecutively within 30 minutes or use the on-body infuser of PCSK9 inhibitors in the treatment hyperlipoproteinemia.";s:7:"keyword";s:21:"pcsk9 inhibitors dose";s:5:"links";s:519:"<a href="http://sljco.coding.al/o23k1sc/white-siding-house-566a7f">White Siding House</a>,
<a href="http://sljco.coding.al/o23k1sc/how-to-build-pantry-shelves-566a7f">How To Build Pantry Shelves</a>,
<a href="http://sljco.coding.al/o23k1sc/3d-origami-skull-instructions-566a7f">3d Origami Skull Instructions</a>,
<a href="http://sljco.coding.al/o23k1sc/2011-ford-fiesta-titanium-566a7f">2011 Ford Fiesta Titanium</a>,
<a href="http://sljco.coding.al/o23k1sc/rosalie-crutchley-death-566a7f">Rosalie Crutchley Death</a>,
";s:7:"expired";i:-1;}
Mini Shell