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a:5:{s:8:"template";s:3196:"<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html lang="en"> <head profile="http://gmpg.org/xfn/11"> <meta content="text/html; charset=utf-8" http-equiv="Content-Type"/> <title>{{ keyword }}</title> <style rel="stylesheet" type="text/css">@font-face{font-family:Roboto;font-style:normal;font-weight:400;src:local('Roboto'),local('Roboto-Regular'),url(https://fonts.gstatic.com/s/roboto/v20/KFOmCnqEu92Fr1Mu4mxP.ttf) format('truetype')}@font-face{font-family:Roboto;font-style:normal;font-weight:900;src:local('Roboto Black'),local('Roboto-Black'),url(https://fonts.gstatic.com/s/roboto/v20/KFOlCnqEu92Fr1MmYUtfBBc9.ttf) format('truetype')} html{font-family:sans-serif;-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%}body{margin:0}a{background-color:transparent}a:active,a:hover{outline:0}h1{margin:.67em 0;font-size:2em}/*! 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Despite rapid advances in recent years, the molecular mechanism underlying embryo implantation remains poorly understood. For the first set of animals, male C57BL/6J mice (2-, 12-, and 15-month-old) were treated with a control methionine diet (0.86% Met) and methionine restriction diet (0.17% Met) for 3 months (n = 10) (Fig. The association of RNA modification in cancer has recently been highlighted. In this study, we found that METTL8 expression was significantly up-regulated in canine mammary tumor and investigated its functional roles in the tumor process, including cancer cell … It is thought by many that diminution of telomere size is associated with cell ageing. For cell depletion in the EMT6 tumour model, NK cells were depleted with anti-asialo-GM1 antibody (30 μl per mouse, clone poly21460, BioLegend) on days −1, +1 and +6 of tumour challenge. We surveyed the single-cell transcriptomic landscape of ovaries from young and aged non-human primates (NHPs) and identified seven ovarian cell types with distinct gene-expression signatures, including oocyte and six types of ovarian somatic cells. Molecular mechanisms of ovarian aging and female age-related fertility decline remain unclear. Methyltransferase like 8 (METTL8) is an enzyme and its role in mRNA m3C modification has barely been studied. As a crucial step for human reproduction, embryo implantation is a low-efficiency process. Here, we used the mouse as an animal model and generated a single-cell transcriptomic atlas of embryo implantation sites. 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