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class="site-content" id="content"> <div class="container"> {{ text }} <br> {{ links }} </div> </div> <footer class="site-footer " id="colophon"> <div class="container"> </div> <div class="site-info"> <div class="container"> {{ keyword }} 2021</div> </div> </footer> </div> </body> </html>";s:4:"text";s:28354:"The Cov-Boost trial, led by University Hospital Southampton NHS Foundation Trust, will look at seven different COVID-19 vaccines, including Valneva’s inactivated vaccine VLA2001, as potential boosters. French-Austrian vaccine developer Valneva on Wednesday announced that it had launched a Phase 3 trial of its candidate vaccine against COVID-19 -- the last testing stage before seeking regulatory approval. Trial Results. The UK funded several key trials of the vaccine … This was mainly driven by investments in Valneva’s COVID-19 vaccine VLA2001 as well as Phase 3 clinical study costs for Valneva’s chikungunya vaccine program VLA1553. The vaccine is undergoing clinical trials. But it has caught the eye of governments in the UK, Europe and Australia. Kelly Garner, Senior Project Manager said: "It is an incredible opportunity and privilege to have a leading role with Pharm-Olam, supporting Valneva with their VLA2001 COVID-19 vaccine candidate, of which the UK Government have secured 100 million doses. Valneva has the only whole virus, inactivated, adjuvanted vaccine candidate in clinical trials against COVID-19 in Europe and we believe our VLA2001 vaccine … If approved, Valneva’s vaccine will not only help tackle Covid-19 here in the UK, but aid our mission to ensure there is a fair supply of vaccines across the globe. But it has caught the eye of governments in the UK, Europe and Australia. When injected into the body, the lab-made peptides prod the immune system to build antibodies and gear up other immune cells to attack the corona… A coronavirus vaccine candidate developed by French biotech Valneva has launched manufacturing in Scotland, the company announced Thursday. The UK government has pre-ordered 60 million doses of the vaccine… Today, the European Commission concluded exploratory talks with the pharmaceutical company Valneva with a view to purchasing its potential vaccine against COVID-19. Valneva is set to begin manufacturing doses of its COVID-19 vaccine for commercial use at its site in Livingston, Scotland, according to The Mail on Sunday.. Valneva’s Phase 3 trial – called Cov-Compare – will compare the immune response generated by its vaccine with that of the vaccine developed jointly by AstraZeneca AZN, … Valneva's vaccine can be stored at standard cold-chain conditions (2-8 degrees Celsius) and is expected to be given as two shots. The inactivation process preserves the structure of the virus’ S protein and is expected to induce a strong immune response. Valneva, a specialty vaccine company focused on the development and commercialisation of prophylactic vaccines for infectious diseases with significant unmet medical need, has announced positive data for Part A of the Phase I/II clinical trial of its inactivated, adjuvanted Covid-19 vaccine candidate, VLA2001. A Covid vaccine that is being manufactured in Scotland has shown a “strong immune response” of up to 90 per cent in early trials.. French biotech company Valneva, which … Live COVID updates from the UK and around the world 36,985,447 People vaccinated in UK > COVID-19 vaccine messaging that focuses on personal benefits is most effective with those who are hesitant May 14, 2021 COVID-19 mRNA vaccines are immunogenic in … French biotech Valneva, which has developed a lineup of traveler vaccines and is starting a late-stage COVID vax effort, is seeking to level up to the Nasdaq with a $100 million IPO. French biotech company Valneva has launched a pivotal Phase 3 trial for its experimental COVID-19 vaccine -- the last step before seeking regulatory approval. Valneva SE announced this week that it will no longer prioritize centralized discussions with the European Commission regarding the distribution of its inactivated, adjuvanted COVID-19 vaccine candidate VLA2001 but instead move to bilateral, country-by-country discussions. By Lina Saigol . A patient receiving an injection of the Moderna Covid-19 vaccine as part of the UK-wide study ... "“Valneva’s vaccine is the type known as an inactivated whole virus vaccine. Meanwhile, preliminary results announced on Apr 6 from the trials of the Valneva Covid-19 vaccine, which is set to be manufactured in the UK, have shown it produces a … Developed by the specialty vaccine company Valneva, the vaccine is being manufactured at the company’s site in Livingston, West Lothian, and is the only inactivated, adjuvanted (an ingredient to create a stronger immune response) COVID-19 vaccine in clinical development in Europe. Valneva on Tuesday reported positive results for its COVID-19 vaccine in early stage clinical trials and said it planned to launch a Phase Three trial this month. As part of this agreement, Valneva is set to provide the UK with 60 million doses in the second half of 2021, depending on the vaccine’s success in … Valneva SE plans to start final-phase clinical trials on its Covid-19 vaccine candidate this month, a step forward for a French drugmaker’s low-tech shot that’s being backed by the UK government. Unlike other vaccines on the market, Valneva's shot is based on an "inactivated" version of the Coronavirus itself. The UK could receive up to 60 million doses of the vaccine candidate by the end of the year, if approved. One of the vaccine’s main selling points is its apparent ability to mount a more general immune response against SARS-CoV-2, the virus that causes COVID-19, rather than rely on the spike protein to do this. Valneva joins the phase 3 Covid-19 vaccine club. The French-headquartered company’s chief executive officer Thomas Lingelbach also said that the COVID-19 vaccine, known as VLA2001, could be made available in Britain between July and September. Valneva SE announced this week that it will no longer prioritize centralized discussions with the European Commission regarding the distribution of its inactivated, adjuvanted COVID-19 vaccine candidate VLA2001 but instead move to bilateral, country-by-country discussions. A key investment theme since the onset of the pandemic has been companies working on the vaccine against COVID-19. Valneva they use inactive vaccines, a species that has been used for the past 100 years to vaccinate billions of people against diseases such as the flu, hepatitis A, polio, and rabies.It works by injecting HIV which is very weak to cause infection but strong enough to trigger the immune system. Meanwhile, preliminary results announced on Apr 6 from the trials of the Valneva Covid-19 vaccine, which is set to be manufactured in the UK, have shown it produces a … Valneva is seeking to raise up to €85m in its planned share offering as the French vaccine maker moves to capitalise on promising early-stage trial results for its Covid-19 jab.. An immediate family member or household member of the study's personnel. A COVID-19 vaccine from French company Valneva has yet to complete clinical trials. The UK government has signed a €1.4 billion ($1.66 billion) order for up to 190 million doses of a coronavirus vaccine in development at French company Valneva. Valneva announced yesterday that a phase 3 trial will compare its COVID-19 vaccine candidate to AstraZeneca’s jab, which is conditionally approved in the EU under the brand name Vaxzevria. 13-04-2021. VLA2001 is currently the only inactivated vaccine candidate in clinical trials against COVID-19 in Europe. essentially, how does the level of antibodies induced by the Valneva vaccine compared with that of Astro's vaccine and more importantly, is the vaccine safe. "We believe that at least one of our discussions is very advanced," its chief financial officer David Lawrence told Reuters, without revealing the other party involved. Government in talks with France’s Valneva over COVID-19 vaccine candidate. Valneva has started a pivotal phase 3 test for its experimental COVID-19 vaccine in a head-to-head against AstraZeneca's conditionally approved pandemic shot Vaxzevria. Valneva Reports Positive Phase 1/2 Data for Its Inactivated, Adjuvanted COVID-19 Vaccine Candidate, VLA2001 Dynavax Technologies reported positive results in 153 adults aged 18 years to 55 years for Part A of the Phase-1 clinical trial of Valneva SE’s inactivated COVID-19 vaccine candidate, VLA2001, that uses Dynavax’s CpG 1018 adjuvant. The Valneva Covid-19 vaccine, which is set to be manufactured in the UK, produces a “strong immune response”, Health Secretary Matt Hancock has … The study aims to recruit <unk> volunteers which will compare Valneva vaccine with Astro's COVID-<unk> vaccine candidate. The GSK/Sanofi and Valneva … The Valneva vaccine works by taking the inactive virus, containing whole bacteria or viruses which have been killed. French biotech Valneva, which has developed a lineup of traveler vaccines and is starting a late-stage COVID vax effort, is seeking to level up to the Nasdaq with a $100 million IPO. Valneva begins first UK clinical trials for its promising COVID-19 vaccine, being developed in Livingston, West Lothian; the UK government has pre-ordered 60 million vaccine doses Valneva’s VLA2001 vaccine is the only inactivated, adjuvanted Covid vaccine in clinical development in Europe. The vaccines taskforce secured 40m doses of the Pfizer/BioNTech vaccine, the first coronavirus shot to be approved by the medicines regulator. How the Valneva vaccine compares to other Covid jabs - and when it could be ready Large-scale manufacturing of a coronavirus vaccine candidate from French biotech company Valneva has begun in Scotland The UK has a contract with the company for up to 190m doses, which will be made in Livingston, West Lothian. Valneva has added hundreds of staff and plans to go from output of about three million vaccines a year to more than 100 million next year if the Covid shot is successful. But it has caught the eye of governments in the UK, Europe and … It will need to be able to prove its safety and effectiveness before being handed the green light for distribution. The French pharmaceutical firm, set to … Excluding COVID … The Covid-19 vaccine being made in West Lothian will be delivered later than expected, manufacturer Valneva has said. Valneva has started a pivotal phase 3 test for its experimental COVID-19 vaccine in a head-to-head against AstraZeneca's conditionally approved pandemic shot Vaxzevria. That's what the study is … Receipt of any vaccine (licensed or investigational), other than licensed influenza vaccine, within 28 days prior to the expected day of randomization (Visit 1). But it has caught the eye of governments in the UK, Europe and Australia. Friday February 05 2021, 12.00pm, The Times. As the world awaits pivotal US data on Novavax’s Covid-19 jab, plenty of other players are still trying to get in on the second wave of vaccines. French biotech company Valneva begins the first clinical trials of its COVID-19 vaccine candidate in sites across the U.K., the government said on Wednesday. Positive Phase 1/2 Results for Valneva's Inactivated COVID-19 Vaccine Candidate Using Dynavax's CpG 1018™ Adjuvant. A COVID-19 vaccine from French company Valneva has yet to complete clinical trials. Valneva has started a pivotal Phase III Cov-Compare (VLA2001-301) clinical trial of its inactivated, Covid-19 vaccine candidate, VLA2001. The Covid-19 vaccine being made in West Lothian will be delivered later than expected, manufacturer Valneva has said. The study aims to recruit <unk> volunteers which will compare Valneva vaccine with Astro's COVID-<unk> vaccine candidate. Valneva, which manufactures its Covid vaccine at a plant in Livingston, said the results of their phase one/two study showed the vaccine was "highly immunogenic with more than 90% of … The UK government has pre-ordered 60 million doses of the candidate, which is … By Elsa Maishman Saturday, 10th April 2021, 7:00 am Health Coronavirus Valneva vaccine: what is the potential new Covid jab, how does it work - and where is it being made in Scotland? The Valneva shot, Europe’s only inactivated vaccine in trials, is hoping to produce a long-term solution against covid-19 and its mutant strains Valneva announced on April 21, 2021 the launch of a Phase III clinical study, the last step before a marketing application, for its candidate vaccine against Covid … Valneva's Covid vaccine is still only in phase I/II trials. The Cov-Boost trial, led by University Hospital Southampton NHS Foundation Trust, will look at seven different COVID-19 vaccines, including Valneva's inactivated vaccine VLA2001, as … COVID-19: Everything you need to know about the Valneva vaccine. Valneva SE is looking at running a head-to-head trial with an approved Covid-19 vaccine for advanced tests of its own shot in the U.K., where the … By Elsa Maishman. BRUSSELS/PARIS (Reuters) -French vaccine maker Valneva has not met the conditions to conclude talks on a deal with the European Union to supply the bloc with its COVID-19 vaccine … Adjuvants are ingredients used in vaccines to … Valneva on Tuesday reported positive results for its COVID-19 vaccine in early stage clinical trials and said it planned to launch a Phase Three trial this month. Valneva’s VLA2001 vaccine is the only inactivated, adjuvanted Covid vaccine in clinical development in Europe. Biotech company Valneva has begun manufacturing a Covid-19 vaccine at its plant in Livingston, West Lothian. A COVID-19 vaccine from French company Valneva has yet to complete clinical trials. The Valneva COVID-19 vaccine is being developed in Livingston, Scotland, and data from an early-stage phase one/two study involving 153 people showed promising results for the jab, paving the way for a phase three clinical trial. A COVID-19 vaccine from French company Valneva has yet to complete clinical trials. The vaccine is said to be made of inactivated “whole virus particles” of Covid-19, reinforced with two adjuvant components. VLA2001 is currently the only inactivated vaccine candidate in clinical trials against COVID-19 in Europe. France furious as Britain snatches Covid vaccine Valneva deal from under its nose. Unlike other vaccines on the market, Valneva's shot is based on an "inactivated" version of the Coronavirus itself. It is one of the most proven types of vaccine… By Elsa Maishman. Kelly Garner, Senior Project Manager said: "It is an incredible opportunity and privilege to have a leading role with Pharm-Olam, supporting Valneva with their VLA2001 COVID-19 vaccine candidate, of which the UK Government have secured 100 million doses. Biotech firm Valneva is working on an inactivated vaccine for COVID-19, which uses a sample of the virus that has been killed to trigger an immune response without creating an … French biotech company Valneva has launched a pivotal Phase 3 trial for its experimental COVID-19 vaccine -- the last step before seeking regulatory approval. Unlike other vaccines on the market, Valneva's shot is based on an "inactivated" version of the Coronavirus itself. Read: French vaccine maker Valneva to launch Phase 3 trial of COVID-19 vaccine it’s making with Dynavax after positive results Valneva said on … Charles Bremner, Paris. UK-made Valneva Covid vaccine produces 'strong immune response', says Matt Hancock 06/04/2021 Comments Off on UK-made Valneva Covid vaccine produces 'strong immune response', says Matt Hancock ANOTHER Covid vaccine has shown huge promise in trials – … Valneva Reports Positive Phase 1/2 Data for Its Inactivated, Adjuvanted COVID-19 Vaccine Candidate, VLA2001 French company Valneva has started manufacturing its Covid vaccine at its Scottish facility with UK supplies expected to be available by the end of 2021 if successful. Excluding COVID-19, research and development investments amounted to €12.1 million in the first quarter of 2021 compared to €13.1 million in the first quarter of 2020. The study aims to recruit <unk> volunteers which will compare Valneva vaccine with Astro's COVID-<unk> vaccine candidate. More than 90 per cent of study participants developed “significant levels of antibodies” against the coronavirus. French biotech company Valneva announced it would start large-scale efficacy trials of its coronavirus vaccine candidate later this month after safety results showed it produced an immune response.. essentially, how does the level of antibodies induced by the Valneva vaccine compared with that of Astro's vaccine and more importantly, is the vaccine safe. The Valneva Covid-19 vaccine, which is set to be made in Scotland, produces a strong immune response, the French company has said.. As a result, Valneva's vaccine could be more effective at tackling emerging COVID-19 virus variants and, if approved, play a useful role as a booster vaccine. Researchers of the latest Covid-19 vaccine have begun recruiting volunteers for a trial of the new jab. Peptides mimic important structures within the coronavirus proteins, including a part of the spike protein used to break into cells. The Covid-19 vaccine being made by Valneva in Livingston, West Lothian has entered phase 3 trials, with a call for 4,000 volunteers. April 6, 2021 expert reaction to press release from Valneva reporting phase 1 and 2 data of its COVID-19 vaccine candidate . A Covid vaccine that is being manufactured in Scotland has shown a “strong immune response” of up to 90 per cent in early trials.. French biotech company Valneva, which … The Valneva Covid-19 vaccine, which is set to be manufactured in the UK, produces a “strong immune response”, Health Secretary Matt Hancock has … A new COVID-19 vaccine could protect people ‘very strongly’ against variants of the virus, Professor Luke O’Neill says. By Elsa Maishman Saturday, 10th April 2021, 7:00 am The Chinese firms Sinovac and Sinopharm are already testing inactivated virus vaccines for COVID-19 in Phase III clinical trials. Valneva has reported positive early results for its Covid-19 vaccine, giving the UK government a potential domestic supply of a shot that could be used as a booster or to tackle virus variants. Around 150 people have taken part in the Northumbria Healthcare trial so far and have received their first dose of either the Valneva or Oxford/Astra Zeneca vaccine. That's what the study is … The Covid-19 vaccine being made in West Lothian will be delivered later than expected, manufacturer Valneva has said. The Covid-19 vaccine being made by Valneva in Livingston, West Lothian has entered phase 3 trials, with a call for 4,000 volunteers. HEALTH-CORONAVIRUS/VALNEVA (CORRECTED, REPEAT, PIX):REFILE-RPT--Valneva open to partners for COVID-19 vaccine as it looks beyond Europe These tests will show whether the vaccine … How about results from clinical trials? Receipt of medications and or vaccinations intended to prevent COVID-19. Excluding COVID … Any member of the study team or sponsor. Monday, 26th April 2021, 7:00 am. Valneva SE is looking at running a head-to-head trial with an approved Covid-19 vaccine for advanced tests of its own shot in the U.K., where the … 2020 January February responses March responses April responses May responses June responses July responses August responses September responses October responses November responses December responses 2021 January responses February responses March responses April responses May responses Locations By continent Africa Antarctica Asia Europe North America Oceania South America By conveyance Cruise ships By Lina Saigol . If approved, it would deliver up to … Adjuvants are ingredients used in vaccines to … VLA2001, an inactivated COVID-19 vaccine candidate with CpG 1018 adjuvant, was highly immunogenic and generally safe and well tolerated. The Valneva Covid-19 vaccine, which is set to be manufactured in the UK, produces a “strong immune response”, Health Secretary Matt Hancock has said. The U.K's big outlay to Valneva, a relative unknown in the hunt for a COVID-19 vaccine—at least compared with the Big Pharmas in the race—is its latest major investment to … By Sara Rigby, PA Science. Valneva’s drug is an inactivated vaccine, meaning it contains dead Covid-19 particles that prompt the body to produce antibodies. The Valneva candidate vaccine is being tested on 150 volunteers at testing sites in Birmingham, Bristol, Newcastle and Southampton. Valneva Covid vaccine could add to the UK's library of jabs Credit: AFP. The vaccine also induced T-cell responses, which help the body fend off … As an overview, Valneva, a French company, is developing the first inactivated COVID-19 vaccine that's entered clinical trials in the European Union. Health Covid in Scotland: Positive early results from Livingston Valneva vaccine site Valneva has reported early positive results for the Covid-19 vaccine being manufactured in Scotland. The … The Cov-Boost trial, led by University Hospital Southampton NHS Foundation Trust, will look at seven different COVID-19 vaccines, including Valneva's inactivated vaccine VLA2001, as … The vaccine has been developed by vaccine company Valneva and is the only inactivated, adjuvanted vaccine in clinical development in Europe, according to the company. More than 90 per cent of study participants developed “significant levels of antibodies” against the coronavirus. PARIS (Reuters) – Some EU countries still want Brussels to strike a deal to buy Valneva’s COVID-19 vaccine candidate despite a recent setback in talks, as the bloc aim to shore up and diversify supplies, sources familiar with the talks told Reuters. Cov-Compare (VLA2001-301) is a randomized, observer-blind, controlled, comparative immunogenicity trial in approximately 4,000 adults. This was mainly driven by investments in Valneva’s COVID-19 vaccine VLA2001 as well as Phase 3 clinical study costs for Valneva’s chikungunya vaccine program VLA1553. Valneva’s Phase 3 clinical trial will test a new vaccine (known as VLA2001) against COVID-19 and its ability to induce antibodies as a protection against the virus. Johnson & Johnson’s jab is the latest COVID-19 vaccine to be linked to rare cases of blood clots, prompting… Coronavirus COVID-19 Vaccine Janssen Focus On Infectious diseases Janssen Johnson & Johnson Pharmaceutical Public health Regulation US FDA USA Vaccines As the world reels under waves of pandemic caused to to variants of COVID-19 virus, a vaccine being developed by a French firm may well offer a solution for the long-term fight against the deadly ailment. Valneva’s vaccine is based on a more traditional technology than those now being rolled out in Britain. We are proud to be collaborating with Valneva on the development of this vaccine for COVID-19 and are committed to supporting Valneva in making the vaccine available." 6 issues for £9.99 when you subscribe to BBC Science Focus Magazine. The inactivated adjuvanted vaccine was "generally safe and well tolerated" in a combined Phase 1/2 trial, according to a statement from the company. But it has caught the eye of governments in the UK, Europe and Australia. Valneva, which has just struck a deal to supply Britain with its potential COVID-19 vaccine, is in very advanced talks with another possible customer, the French firm's CFO said. France-based Valneva SE today announced it would participate in a clinical trial looking at different COVID-19 ‘booster’ vaccines. essentially, how does the level of antibodies induced by the Valneva vaccine compared with that of Astro's vaccine and more importantly, is the vaccine safe. Madeleine Armstrong; Meanwhile, Ocugen hopes that Covaxin's India data will be enough for US approval. Valneva Covid vaccine could add to the UK's library of jabs Credit: AFP. LARGE-SCALE MANUFACTURING of a Covid-19 vaccine candidate from French biotech company Valneva has begun in Scotland. But it has caught the eye of governments in the UK, Europe, and Australia. VLA2001 has inactivated whole virus particles of SARS-CoV-2 with high S-protein density and two adjuvants, alum and Dynavax’s CpG 1018. Saint-Herblain (France), May 19, 2021 – Valneva SE, a specialty vaccine company focused on the development and commercialization of prophylactic vaccines for infectious diseases with significant unmet medical need, today announced it will participate in a UK government-funded clinical trial looking at different COVID-19 ‘booster’ vaccines that launches today. How it works: COVAXX designed small pieces of protein, called peptides, from several of the proteins from SARS-CoV-2, the coronavirus that causes COVID-19. Saint-Herblain (France), May 19, 2021 – Valneva SE, a specialty vaccine company focused on the development and commercialization of prophylactic vaccines for infectious diseases with significant unmet medical need, today announced it will participate in a UK government-funded clinical trial looking at different COVID-19 ‘booster’ vaccines that launches today. The vaccine is currently undergoing a Phase 1/2 clinical study, involving 150 “young adults aged 18 to 55 years.” The results of the trials are expected to be available in April. A COVID-19 vaccine from French company Valneva has yet to complete clinical trials. Valneva SE is in advanced discussions with the European Commission (EC) for the supply of up to 60 million doses of its COVID-19 vaccine, VLA2001. France's Valneva raises new funds to progress its inactivated vaccine, while Scotland launches a new study into 'long COVID', Takeda reports positive interim results from a Japanese trial with Moderna's mRNA vaccine, a setback for GC's plasma therapy, and Celltrion begins exporting a … Valneva have published a press release reporting positive phase 1/2 data for its inactivated, adjuvanted COVID-19 vaccine candidate, VLA2001. That's what the study is … The Sydney Morning Herald 18d: Valneva Announces Launch of Proposed … Published: Apr 06, 2021. Valenva’s vaccine candidate, VLA2001, is a highly purified, inactivated vaccine candidate against the SARS-CoV-2 virus that uses manufacturing technology from Valneva’s Japanese Encephalitis Vaccine. A COVID-19 vaccine from French company Valneva has yet to complete clinical trials. CDC and FDA recommend pausing J&J COVID-19 vaccine use. Valneva The Pfizer, Oxford/AstraZeneca and Moderna vaccines are in use, while J&J and Novavax have both published phase three data and look set to be approved soon. Valneva has pulled out of talks with EU bosses who wanted to buy its Covid vaccine, in another blow to the bloc's shambolic roll-out. PEOPLE who have not yet had a Covid jab are being urged to sign up to take part in a trial for a new Covid-19 vaccine produced by Valneva. This was mainly driven by investments in Valneva’s COVID-19 vaccine VLA2001 as well as Phase 3 clinical study costs for Valneva’s chikungunya vaccine program VLA1553. A coronavirus vaccine candidate developed by French biotechnology company Valneva has launched manufacturing in Scotland, the company announced Thursday. Last September, Valneva entered a partnership with the UK government for the supply of up to 190 million doses of its COVID-19 vaccine. Monday, 26th April 2021, 7:00 am. Valneva SE is in advanced discussions with the European Commission (EC) for the supply of up to 60 million doses of its COVID-19 vaccine, VLA2001. COVID-19: Valneva begins clinical trials for new coronavirus vaccine in UK. We are proud to be collaborating with Valneva on the development of this vaccine for COVID-19 and are committed to supporting Valneva in making the vaccine available." The vaccine candidate is being manufactured in Livingston The trial is now recruiting 4,000 people aged 18 years and over in the UK to help evaluate the VLA2001 vaccine compared to a … By Matthias Blamont. The vaccine is being developed by a company named Valneva SE and it can be more 'variant-proof'. The UK has ordered an extra 40 million doses of a coronavirus vaccine from the French pharmaceutical company Valneva, that should become available later in the year and into 2022. 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