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</html>";s:4:"text";s:31302:"Genetic Disorders Among Arab Populations. CTGA: the database for genetic disorders in Arab populations. Please enable it to take advantage of the complete set of features! The Catalogue for Transmission Genetics in Arabs (CTGA) database, hosted online at https://cags.org.ae/ (accessed on 29 July 2021), is a compendium of bibliographic data on genetic disorders in Arabs, compiled and curated through searches on PubMed and Index Medicus . The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. Prevention and treatment information (HHS). Strong evidence exists to show that metabolic diseases constitute a significant cause of neonatal and infant death among Arabs.12 Therefore, screening programmes using the Guthrie system would be valuable in the prevention and early treatment of these disorders. DOHA, QATAR — A new study can help with future research into the genetic risk factors that are specific to the Arab population, including those that are shared with other ethnicities. I knew that three sisters who were distantly related to me had some problems, which I thought could have happened by chance or because their mother was old when she had them. This publication is of value for all those interested in clinical genetics. Readers are updated on recent developments and global challenges in their specialist field. Many of the nearly 500 genes studied in Arab people revealed striking spectra of heterogeneity with many novel and rare mutations causing large arrays of clinical outcomes. In most Arab countries, except Tunisia,w5 selective termination of pregnancy is not legally available. Israel is working on an "ethnically targeted" biological weapon that would kill or harm Arabs but not Jews, according to Israeli military and western intelligence sources cited in a front-page report in the London Sunday Times, November 15, 1998 ("Israel Planning 'Ethnic' Bomb as Saddam Caves In," by Uzi . Detailed family history should be taken to spot any genetic disease, The couple should be asked about any known inherited disease in the family, history of birth defects, impairment of hearing or vision, learning difficulties, any unexplained neonatal or infant deaths, and failure to thrive among infants, If a genetic disorder is suspected in the family, the couple should be referred to a specialised genetic counselling clinic, If no known inherited disorder exists in the family, first cousins intending to marry are informed of the doubling of the risk for birth defects13, The World Health Organization Eastern Mediterranean Regional Office publication Community Control of Genetic and Congenital Disorders2 provides an outline of the basic requirements to strengthen the capabilities of primary healthcare workers in preventing genetic diseases (box B on bmj.com). Arabs were nomads and pilgars living in the dessert. MeSH If you are unable to import citations, please contact Epub 2020 Jul 27. View Record in Scopus Google Scholar. High fertility rates together with increased consanguineous marriages, generally noticed in Arab populations, tend to increase the rates of genetic and congenital abnormalities. "Here you can study 10 families to study genetic disorders, where you would need 10,000 families to study genetic disorders in the United States." But it's not just Saudi Arabia, or the Middle East for that matter. Careers. Arab populations have their "own" genetic disorders, both universal and particular. They should also be able to provide counselling information about risk and screening for disorders known to be common in these communities, such as thalassaemia, sickle cell disease, and glucose-6-phosphate dehydrogenase deficiency. Inbreeding is surprisingly common in many Muslim nations and communities, evidence shows. It is therefore not surprising that, in each of the villages, a different distribution of genetic diseases . Centre for Arab Genomic Studies (CAGS) in Dubai (United Arab Emirates) reports Arabs suffer from one of the highest rates of genetic disease in the world. S [1] Medical Biochemistry Department & WHO Collaborating Centre for Hemoglobinopathies, King Khalid University, Riyadh, Saudi Arabia Source. See this image and copyright information in PMC. Updated and enlarged second edition. Strategies To Reduce The Incidence Of Genetic Disorders In The Arab World By Prof. Hossam E. Fadel, Noor 1. Among the parents of patients with rare autosomal recessive disorders the consanguinity rate was much higher than the one of the general population (92.5%). Documentation of inherited disorders and mutation frequencies in the different religious communities in Israel in the Israeli National Genetic Database. This site needs JavaScript to work properly. MeSH Clipboard, Search History, and several other advanced features are temporarily unavailable. Keywords: Biomedicine, Human Genetics. By Rachel McArthur. SA-A searched the literature and provided some information relevant to the paper. Bethesda, MD 20894, Help doi: 10.1371/journal.pone.0244567. Molecular Chaperones in Human Disorders, Volume 114 in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair and their involvement in maintaining ... eCollection 2021. I am six months pregnant now, and ultrasound has shown that the baby is affected. Saudi medical journal. It generates actionable genetic and clinical information for all who suffer from hereditary heart conditions, have family members suffer or being diagnosed with a medically . 615-621. In this trailblazing book, Dr. Moalem employs his wide-ranging and entertaining interdisciplinary approach to science and medicine-- explaining how art, history, superheroes, sex workers, and sports stars all help us understand the impact ... Be Part of the Largest Effort to Define Genetic Disorders in Arabs. -, Ferembach D. Human remains from the epipaleolithic period in the Taforalt grotto in eastern Morocco. Available data suggest that genetic and congenital disorders are more common in Arab countries than in industrialised countries; recessively inherited disorders account for a substantial proportion of physical and mental handicap.1–3 6 Several factors may contribute to the high prevalence of genetically determined disorders: High consanguinity rates—25-60% of all marriages are consanguineous, and the rate of first cousin marriages is high (figs 1 and 2; table A on bmj.com).4 w1 In addition, isolated subpopulations with a high level of inbreeding exist. 1997 Sep;34(9):765-6. doi: 10.1136/jmg.34.9.765. http://www.census.gov/population/international/data/idb/informationGatew... Hunter-Zinck H, Musharoff S, Salit J, Al-Ali KA, Chouchane L, Gohar A, Matthews R, Butler MW, Fuller J, Hackett NR, Crystal RG, Clark AG. Written by experts in the field. HER2 overexpression is a putative diagnostic and prognostic biomarker for late-stage colorectal cancer in North African patients. As termination is not legal in many Arab countries, the value of introducing prenatal screening programmes is questionable. A retrospective chart review of all Emirati patients assessed by clinical geneticists due to neuro-genetic disorders including global developmental delay, ASD, ID, ADHD, and . H aemoglobin disorders, inherited metabolic diseases, neurogenetic disorders, and birth defects are common among Arab populations. If the results suggest an abnormality, the woman is referred for a detailed anomaly scan, and further invasive techniques, such as amniocentesis, might be needed. 1959;248(24):3465–3467. Found inside – Page 9The bestselling guide to the medical management of common genetic syndromes —now fully revised and expanded A review in the American Journal of Medical Genetics heralded the first edition of Management of Genetic Syndromes as an ... Mark Weber. (Pp 499; £75 hardback.) Available evidence suggests that congenital and genetic disorders are responsible for a major proportion of infant mortality, morbidity, and handicap in Arab countries.1-3 The population of the region is characterised by large family size, high maternal and paternal age, and a high level of inbreeding with consanguinity rates in the range of 25-60%.1 2 4 w1 Certain disorders are common . W.A. Our digital library spans in multiple locations, allowing you to get the most less latency time to download any of our books like this one. technical support for your product directly (links go to external sites): Thank you for your interest in spreading the word about The BMJ. The problem is compounded by a lack of reliable genetic services in all but a handful of Arab countries. Proc Natl Acad Sci U S A. Free Preview. Pre-implantation genetic diagnosis is welcomed in Arab countries, as it does not involve the decision to terminate the pregnancy. Comprehensive open-access database of genetic diseases and variants in the Arab World. Although studying Arab-specific genetic disorders resulted in a high value knowledge base, approximately 35% of genetic diseases in Arabs do not have a defined molecular etiology. The pre-marriage health screening campaign has been launched by the UAE Ministry of Health (MoH) in last March, with clinics at all MoH healthcare centers across the UAE. In addition to genetic diversity, the Arab family is characterized by its large size, high maternity and paternity ages at conception and significant endogamy with consanguinity rates between 25 and 60% which are 100-fold higher than the < 0.2% consanguinity rate in Western countries [].Therefore, it is expected that Arab genomes have a high burden of regions of homozygosity (ROH) leading to a . In this review we provided an overview of Arab gene geography, and various genetic abnormalities in Arab populations, including disorders of blood, metabolic, circulatory and neoplasm, and also discussed their associated molecules or genes responsible for the cause of these disorders. Epub 2009 May 12. Economic cost should also be taken into account. Disclaimer, National Library of Medicine June 22, 2021. Online ahead of print. Autosomal recessive disorders among Arabs: an overview from Kuwait. Consanguinity and reproductive health among Arabs. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. Genetic disorders are frequent in the Arab population of Israel, mainly because of the preference for consanguineous marriages. This often leads to ethical dilemmas.2 5 It is therefore important to clarify the role of ultrasonography for fetal anomalies in obstetric services in this region.2 5. This is the first genetic anthropology study on Arabs in MENA (Middle East and North Africa) region. Genetic disorders, and in particular hemoglobinopathies such as sickle cell anemia and thalassemia are common in Saudi Arabia, especially in the eastern and southern regions. Genetic Counseling in the Middle East Shelley J. Kennedy, Muna Al-Saffar. The Saudi experience indicates that approximately 50% of diseases identified by this method are manageable.11 However, in many cases treatment does not prevent the considerable morbidity. Consanguinity and genetic diseases in North Africa and immigrants to Europe. This new volume teaches readers about current advances in the field, describing the use of induced pluripotent stem cells to model several diseases in vitro, and thus enabling us to study the cellular and molecular mechanisms involved in ... Autosomal recessive disorders among Arabs: an overview from Kuwait. C R Hebd Seances Acad Sci. Found insideGenomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics ... . Share on Facebook Share on Twitter. Unable to load your collection due to an error, Unable to load your delegates due to an error. 1994 Mar;31(3):224-33. doi: 10.1136/jmg.31.3.224. 2009 Sep;41(5):575-81. doi: 10.1017/S0021932009003393. An educational tool on genetic disorders in the region. Altinoz A, Al Ameri M, Qureshi W, Boush N, Nair SC, Abdel-Aziz A. This study reports on the use of whole exome sequencing (WES) to diagnose children with inborn errors of metabolism and other disorders in United Arab Emirates. SBAHC is one of the prominent Saudi facilities that provide specialized healthcare services to patients, especially children with rare disabilities caused by genetic disorders. Arab News. As one doctor put it, genetic problems associated with certain Saudi tribes--from a nervous tic to severe neural disorders--involve "mutations that occurred 10,000 or 20,000 years ago," but . Found inside – Page iThis book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). In Saudi Arabia, a Royal decree was passed in 2003 for a mandatory premarital screening test followed by non-directive genetic counselling for haemoglobinopathies; the decision to marry is then left to the couple. Genetic diversity within these source populations, along with the fact that the rates of inbreeding are often high and family sizes are often large, constitute conditions that facilitate the emergence and detection of phenotypes explained notably by autosomal recessive inheritance; in which case, the use of . Furthermore, in many parts of the Arab world the society is still tribal.5 6 w1 This has made the epidemiology of genetic disorders complicated, as many families and tribal groups are descended from a limited number of ancestors and some conditions are confined to specific villages, families, and tribal groups, leading to an unusual burden of genetic diseases in these communities (table B on bmj.com)1 2 5, The high prevalence of haemoglobinopathies, glucose-6-phosphate dehydrogenase deficiency, autosomal recessive syndromes, and several metabolic disorders (fig A and table C on bmj.com)1 2 5, The rate of children with Down's syndrome in some Arab countries exceeds the 1.2-1.7 per 1000 typical for industrialised countries. Jewish. This book highlights the unprecedented opportunity to improve the lives of children and families in developing countries by preventing some birth defects and reducing the consequences of others. Contributors LA-G developed the idea, searched the literature, wrote the paper, and was responsible for the overall organisation. 8600 Rockville Pike Fragile X Syndrome in a Female With Homozygous Full-Mutation Alleles of the FMR1 Gene. The UAE's Fight Against Genetic Diseases. Comprised of 49 chapters, this volume begins with an overview of what can be learned from the genetic analysis of the lac repressor, followed by a discussion on the topography of the interaction the lac repressor, RNA polymerase, and ... Pediatrics. Oxford University Press, 1997. When I married my cousin, I thought about genetic diseases and the probabilities of my children having those diseases. Certain disorders tend to occur in some ethnic groups more than others. Tadmouri GO, Al Ali MT, Al-Haj Ali S, Al Khaja N. Nucleic Acids Res. A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches. The programme identifies carrier couples before marriage and offers counselling, thus providing them with the opportunity to separate. 82,000-year-old shell beads from North Africa and implications for the origins of modern human behavior. Saudi Arabia has an active selective newborn screening programme for inherited metabolic diseases that reaches 10-20% of newborns. Anwar, M. Khyatti, K. Hemminki. 2019 Sep 12;16(18):3383. doi: 10.3390/ijerph16183383. Genetic Disorders among Arab Populations. GENETIC DISORDERS AND TESTS AVAILABLE IN ARABIAN HORSES. In the Middle East (ME), recessive genetic diseases are one of the leading causes (up to 43%) of infant mortality. 2020 Aug;28(8):1034-1043. doi: 10.1038/s41431-020-0609-9. This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives. This book is the first on the history of both physical and mental disabilities in the Middle East and North Africa during Ottoman rule. Arab genetic disease database (AGDDB): a population-specific clinical and mutation database. Researchers have already identified over 13,000 genetically inherited traits in humans, more than 5,000 of them are disorders or other abnormalities which may be fatal or disabling genetic conditions. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. Bethesda, MD 20894, Help S O Arab - sickle cell disease often causes mild anemia, tiredness or weakness. An indispensable source for human and medical geneticists, genetic counselors, researchers, medical specialists dealing with Arab patients or practicing in Arab countries. Genetic Disorders About Familial Mediterranean Fever Familial Mediterranean Fever (FMF) is an inherited disease, characterized by recurrent attacks of fever, inflammation of the abdominal lining (peritonitis), inflammation of the lining surrounding the lungs , painful, swollen joints, and a characteristic ankle rash. Thus, we were not able to confirm the suggestion that there is an increase risk for trisomies in children/grandchildren of consanguineous parents. 2007;104(24):9964–9969. Based on these results, genetic tests are being developed to predict the course of the disease, potential targeted therapies, and drug repurposing candidates are being evaluated," he said. The first release of the database is populated primarily with information . Some of these registries report to the International Clearing House for Birth Defects.w8. 2004 May;113(5):e472-86. Genetic disorders, and in particular hemoglobinopathies such as sickle cell anemia and thalassemia are common in Saudi Arabia, especially in the eastern and southern regions. Pre-implantation genetic diagnosis involves assisted reproductive technology. ROSTOCK and BERLIN, Germany - (Arab Newswire) -- arcensus GmbH is proud to announce the launch of its direct-to-consumer myLifeHeart™ service, based on Whole Genome Sequencing (WGS) in the Kingdom of Saudi Arabia. The geneticist explained to us that it is inherited and I have 25% risk of having another affected child. Clipboard, Search History, and several other advanced features are temporarily unavailable. Found insideThis second edition is significantly expanded with 21 new chapters covering dermatology for geriatric, adolescent, and pregnant patients, as well as depigmenting agents, viral infections, cutaneous manifestation of internal malignancy, ... Consanguinity and recurrence risk of birth defects: a population based study, https://doi.org/10.1136/bmj.38982.704931.AE, Maidstone and Tunbridge Wells NHS Trust: Consultant Clinical/Medical and Acute Oncologists, Midlands Partnership NHS Foundation Trust: Consultant in Perinatal Psychiatrist, Essex Partnership University NHS Foundation Trust: Consultant Psychiatrist in Child and Adolescent Psychiatry, Essex Partnership University NHS Foundation Trust: Consultant Psychiatrist in Child Adolescent Psychiatry, Essex Partnership University NHS Foundation Trust: Consultant in Eating Disorders, Women’s, children’s & adolescents’ health. One of the most important aspects of prevention programmes for genetic disorders is to have a well informed and educated population. A detailed study of countries for which surveys on the occurrence of genetic disorders have been completed (United Arab Emirates, Bahrain, and Oman) indicates that recessive disorders are more in number than the dominant ones [80-82]. Screening extended families for genetic hemoglobin disorders in Pakistan, A new era for preventive genetic programs in the Arabian Peninsula. Data about rare genetic disorders in Iraqi patients is not available. It is available in Saudi Arabia, where several single gene disorders can be diagnosed.11 w11 Various numerical chromosome aberrations such as trisomies 21, 13, and 18 and sex chromosome abnormalities are being diagnosed in Jordan by use of the fluorescent in situ hybridisation technique after in vitro fertilisation in a few private obstetric hospitals.6 Pre-implantation genetic diagnosis for common disorders such as β thalassaemia could be included in future prevention programmes. 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