Current File : /var/www/html/diaspora/api_internal/public/lbfc/cache/94e3e4c036f095e4b6d80eadd1c28e6a
a:5:{s:8:"template";s:15011:"<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8"/>
<meta content="IE=edge" http-equiv="X-UA-Compatible">
<meta content="text/html; charset=utf-8" http-equiv="Content-Type">
<meta content="width=device-width, initial-scale=1, maximum-scale=1" name="viewport">
<title>{{ keyword }}</title>
<style rel="stylesheet" type="text/css">.wc-block-product-categories__button:not(:disabled):not([aria-disabled=true]):hover{background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #e2e4e7,inset 0 0 0 2px #fff,0 1px 1px rgba(25,30,35,.2)}.wc-block-product-categories__button:not(:disabled):not([aria-disabled=true]):active{outline:0;background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #ccd0d4,inset 0 0 0 2px #fff}.wc-block-product-search .wc-block-product-search__button:not(:disabled):not([aria-disabled=true]):hover{background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #e2e4e7,inset 0 0 0 2px #fff,0 1px 1px rgba(25,30,35,.2)}.wc-block-product-search .wc-block-product-search__button:not(:disabled):not([aria-disabled=true]):active{outline:0;background-color:#fff;color:#191e23;box-shadow:inset 0 0 0 1px #ccd0d4,inset 0 0 0 2px #fff} *{box-sizing:border-box}.fusion-clearfix{clear:both;zoom:1}.fusion-clearfix:after,.fusion-clearfix:before{content:" ";display:table}.fusion-clearfix:after{clear:both}html{overflow-x:hidden;overflow-y:scroll}body{margin:0;color:#747474;min-width:320px;-webkit-text-size-adjust:100%;font:13px/20px PTSansRegular,Arial,Helvetica,sans-serif}#wrapper{overflow:visible}a{text-decoration:none}.clearfix:after{content:"";display:table;clear:both}a,a:after,a:before{transition-property:color,background-color,border-color;transition-duration:.2s;transition-timing-function:linear}#main{padding:55px 10px 45px;clear:both}.fusion-row{margin:0 auto;zoom:1}.fusion-row:after,.fusion-row:before{content:" ";display:table}.fusion-row:after{clear:both}.fusion-columns{margin:0 -15px}footer,header,main,nav,section{display:block}.fusion-header-wrapper{position:relative;z-index:10010}.fusion-header-sticky-height{display:none}.fusion-header{padding-left:30px;padding-right:30px;-webkit-backface-visibility:hidden;backface-visibility:hidden;transition:background-color .25s ease-in-out}.fusion-logo{display:block;float:left;max-width:100%;zoom:1}.fusion-logo:after,.fusion-logo:before{content:" ";display:table}.fusion-logo:after{clear:both}.fusion-logo a{display:block;max-width:100%}.fusion-main-menu{float:right;position:relative;z-index:200;overflow:hidden}.fusion-header-v1 .fusion-main-menu:hover{overflow:visible}.fusion-main-menu>ul>li:last-child{padding-right:0}.fusion-main-menu ul{list-style:none;margin:0;padding:0}.fusion-main-menu ul a{display:block;box-sizing:content-box}.fusion-main-menu li{float:left;margin:0;padding:0;position:relative;cursor:pointer}.fusion-main-menu>ul>li{padding-right:45px}.fusion-main-menu>ul>li>a{display:-ms-flexbox;display:flex;-ms-flex-align:center;align-items:center;line-height:1;-webkit-font-smoothing:subpixel-antialiased}.fusion-main-menu .fusion-dropdown-menu{overflow:hidden}.fusion-caret{margin-left:9px}.fusion-mobile-menu-design-modern .fusion-header>.fusion-row{position:relative}body:not(.fusion-header-layout-v6) .fusion-header{-webkit-transform:translate3d(0,0,0);-moz-transform:none}.fusion-footer-widget-area{overflow:hidden;position:relative;padding:43px 10px 40px;border-top:12px solid #e9eaee;background:#363839;color:#8c8989;-webkit-backface-visibility:hidden;backface-visibility:hidden}.fusion-footer-widget-area .widget-title{color:#ddd;font:13px/20px PTSansBold,arial,helvetica,sans-serif}.fusion-footer-widget-area .widget-title{margin:0 0 28px;text-transform:uppercase}.fusion-footer-widget-column{margin-bottom:50px}.fusion-footer-widget-column:last-child{margin-bottom:0}.fusion-footer-copyright-area{z-index:10;position:relative;padding:18px 10px 12px;border-top:1px solid #4b4c4d;background:#282a2b}.fusion-copyright-content{display:table;width:100%}.fusion-copyright-notice{display:table-cell;vertical-align:middle;margin:0;padding:0;color:#8c8989;font-size:12px}.fusion-body p.has-drop-cap:not(:focus):first-letter{font-size:5.5em}p.has-drop-cap:not(:focus):first-letter{float:left;font-size:8.4em;line-height:.68;font-weight:100;margin:.05em .1em 0 0;text-transform:uppercase;font-style:normal}:root{--button_padding:11px 23px;--button_font_size:13px;--button_line_height:16px}@font-face{font-display:block;font-family:'Antic Slab';font-style:normal;font-weight:400;src:local('Antic Slab Regular'),local('AnticSlab-Regular'),url(https://fonts.gstatic.com/s/anticslab/v8/bWt97fPFfRzkCa9Jlp6IacVcWQ.ttf) format('truetype')}@font-face{font-display:block;font-family:'Open Sans';font-style:normal;font-weight:400;src:local('Open Sans Regular'),local('OpenSans-Regular'),url(https://fonts.gstatic.com/s/opensans/v17/mem8YaGs126MiZpBA-UFVZ0e.ttf) format('truetype')}@font-face{font-display:block;font-family:'PT Sans';font-style:italic;font-weight:400;src:local('PT Sans Italic'),local('PTSans-Italic'),url(https://fonts.gstatic.com/s/ptsans/v11/jizYRExUiTo99u79D0e0x8mN.ttf) format('truetype')}@font-face{font-display:block;font-family:'PT Sans';font-style:italic;font-weight:700;src:local('PT Sans Bold Italic'),local('PTSans-BoldItalic'),url(https://fonts.gstatic.com/s/ptsans/v11/jizdRExUiTo99u79D0e8fOydLxUY.ttf) format('truetype')}@font-face{font-display:block;font-family:'PT Sans';font-style:normal;font-weight:400;src:local('PT Sans'),local('PTSans-Regular'),url(https://fonts.gstatic.com/s/ptsans/v11/jizaRExUiTo99u79D0KEwA.ttf) format('truetype')}@font-face{font-display:block;font-family:'PT Sans';font-style:normal;font-weight:700;src:local('PT Sans Bold'),local('PTSans-Bold'),url(https://fonts.gstatic.com/s/ptsans/v11/jizfRExUiTo99u79B_mh0O6tKA.ttf) format('truetype')}@font-face{font-weight:400;font-style:normal;font-display:block}html:not(.avada-html-layout-boxed):not(.avada-html-layout-framed),html:not(.avada-html-layout-boxed):not(.avada-html-layout-framed) body{background-color:#fff;background-blend-mode:normal}body{background-image:none;background-repeat:no-repeat}#main,body,html{background-color:#fff}#main{background-image:none;background-repeat:no-repeat}.fusion-header-wrapper .fusion-row{padding-left:0;padding-right:0}.fusion-header .fusion-row{padding-top:0;padding-bottom:0}a:hover{color:#74a6b6}.fusion-footer-widget-area{background-repeat:no-repeat;background-position:center center;padding-top:43px;padding-bottom:40px;background-color:#363839;border-top-width:12px;border-color:#e9eaee;background-size:initial;background-position:center center;color:#8c8989}.fusion-footer-widget-area>.fusion-row{padding-left:0;padding-right:0}.fusion-footer-copyright-area{padding-top:18px;padding-bottom:16px;background-color:#282a2b;border-top-width:1px;border-color:#4b4c4d}.fusion-footer-copyright-area>.fusion-row{padding-left:0;padding-right:0}.fusion-footer footer .fusion-row .fusion-columns{display:block;-ms-flex-flow:wrap;flex-flow:wrap}.fusion-footer footer .fusion-columns{margin:0 calc((15px) * -1)}.fusion-footer footer .fusion-columns .fusion-column{padding-left:15px;padding-right:15px}.fusion-footer-widget-area .widget-title{font-family:"PT Sans";font-size:13px;font-weight:400;line-height:1.5;letter-spacing:0;font-style:normal;color:#ddd}.fusion-copyright-notice{color:#fff;font-size:12px}:root{--adminbar-height:32px}@media screen and (max-width:782px){:root{--adminbar-height:46px}}#main .fusion-row,.fusion-footer-copyright-area .fusion-row,.fusion-footer-widget-area .fusion-row,.fusion-header-wrapper .fusion-row{max-width:1100px}html:not(.avada-has-site-width-percent) #main,html:not(.avada-has-site-width-percent) .fusion-footer-copyright-area,html:not(.avada-has-site-width-percent) .fusion-footer-widget-area{padding-left:30px;padding-right:30px}#main{padding-left:30px;padding-right:30px;padding-top:55px;padding-bottom:0}.fusion-sides-frame{display:none}.fusion-header .fusion-logo{margin:31px 0 31px 0}.fusion-main-menu>ul>li{padding-right:30px}.fusion-main-menu>ul>li>a{border-color:transparent}.fusion-main-menu>ul>li>a:not(.fusion-logo-link):not(.fusion-icon-sliding-bar):hover{border-color:#74a6b6}.fusion-main-menu>ul>li>a:not(.fusion-logo-link):hover{color:#74a6b6}body:not(.fusion-header-layout-v6) .fusion-main-menu>ul>li>a{height:84px}.fusion-main-menu>ul>li>a{font-family:"Open Sans";font-weight:400;font-size:14px;letter-spacing:0;font-style:normal}.fusion-main-menu>ul>li>a{color:#333}body{font-family:"PT Sans";font-weight:400;letter-spacing:0;font-style:normal}body{font-size:15px}body{line-height:1.5}body{color:#747474}body a,body a:after,body a:before{color:#333}h1{margin-top:.67em;margin-bottom:.67em}.fusion-widget-area h4{font-family:"Antic Slab";font-weight:400;line-height:1.5;letter-spacing:0;font-style:normal}.fusion-widget-area h4{font-size:13px}.fusion-widget-area h4{color:#333}h4{margin-top:1.33em;margin-bottom:1.33em}body:not(:-moz-handler-blocked) .avada-myaccount-data .addresses .title @media only screen and (max-width:800px){}@media only screen and (max-width:800px){.fusion-mobile-menu-design-modern.fusion-header-v1 .fusion-header{padding-top:20px;padding-bottom:20px}.fusion-mobile-menu-design-modern.fusion-header-v1 .fusion-header .fusion-row{width:100%}.fusion-mobile-menu-design-modern.fusion-header-v1 .fusion-logo{margin:0!important}.fusion-header .fusion-row{padding-left:0;padding-right:0}.fusion-header-wrapper .fusion-row{padding-left:0;padding-right:0;max-width:100%}.fusion-footer-copyright-area>.fusion-row,.fusion-footer-widget-area>.fusion-row{padding-left:0;padding-right:0}.fusion-mobile-menu-design-modern.fusion-header-v1 .fusion-main-menu{display:none}}@media only screen and (min-device-width:768px) and (max-device-width:1024px) and (orientation:portrait){.fusion-columns-4 .fusion-column:first-child{margin-left:0}.fusion-column{margin-right:0}#wrapper{width:auto!important}.fusion-columns-4 .fusion-column{width:50%!important;float:left!important}.fusion-columns-4 .fusion-column:nth-of-type(2n+1){clear:both}#footer>.fusion-row,.fusion-header .fusion-row{padding-left:0!important;padding-right:0!important}#main,.fusion-footer-widget-area,body{background-attachment:scroll!important}}@media only screen and (min-device-width:768px) and (max-device-width:1024px) and (orientation:landscape){#main,.fusion-footer-widget-area,body{background-attachment:scroll!important}}@media only screen and (max-width:800px){.fusion-columns-4 .fusion-column:first-child{margin-left:0}.fusion-columns .fusion-column{width:100%!important;float:none;box-sizing:border-box}.fusion-columns .fusion-column:not(.fusion-column-last){margin:0 0 50px}#wrapper{width:auto!important}.fusion-copyright-notice{display:block;text-align:center}.fusion-copyright-notice{padding:0 0 15px}.fusion-copyright-notice:after{content:"";display:block;clear:both}.fusion-footer footer .fusion-row .fusion-columns .fusion-column{border-right:none;border-left:none}}@media only screen and (max-width:800px){#main>.fusion-row{display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap}}@media only screen and (max-width:640px){#main,body{background-attachment:scroll!important}}@media only screen and (max-device-width:640px){#wrapper{width:auto!important;overflow-x:hidden!important}.fusion-columns .fusion-column{float:none;width:100%!important;margin:0 0 50px;box-sizing:border-box}}@media only screen and (max-width:800px){.fusion-columns-4 .fusion-column:first-child{margin-left:0}.fusion-columns .fusion-column{width:100%!important;float:none;-webkit-box-sizing:border-box;box-sizing:border-box}.fusion-columns .fusion-column:not(.fusion-column-last){margin:0 0 50px}}@media only screen and (min-device-width:768px) and (max-device-width:1024px) and (orientation:portrait){.fusion-columns-4 .fusion-column:first-child{margin-left:0}.fusion-column{margin-right:0}.fusion-columns-4 .fusion-column{width:50%!important;float:left!important}.fusion-columns-4 .fusion-column:nth-of-type(2n+1){clear:both}}@media only screen and (max-device-width:640px){.fusion-columns .fusion-column{float:none;width:100%!important;margin:0 0 50px;-webkit-box-sizing:border-box;box-sizing:border-box}}</style>
</head>
<body>
<div id="boxed-wrapper">
<div class="fusion-sides-frame"></div>
<div class="fusion-wrapper" id="wrapper">
<div id="home" style="position:relative;top:-1px;"></div>
<header class="fusion-header-wrapper">
<div class="fusion-header-v1 fusion-logo-alignment fusion-logo-left fusion-sticky-menu- fusion-sticky-logo-1 fusion-mobile-logo-1 fusion-mobile-menu-design-modern">
<div class="fusion-header-sticky-height"></div>
<div class="fusion-header">
<div class="fusion-row">
<div class="fusion-logo" data-margin-bottom="31px" data-margin-left="0px" data-margin-right="0px" data-margin-top="31px">
<a class="fusion-logo-link" href="{{ KEYWORDBYINDEX-ANCHOR 0 }}">{{ KEYWORDBYINDEX 0 }}<h1>{{ keyword }}</h1>
</a>
</div> <nav aria-label="Main Menu" class="fusion-main-menu"><ul class="fusion-menu" id="menu-menu"><li class="menu-item menu-item-type-post_type menu-item-object-page current_page_parent menu-item-1436" data-item-id="1436" id="menu-item-1436"><a class="fusion-bar-highlight" href="{{ KEYWORDBYINDEX-ANCHOR 1 }}"><span class="menu-text">Blog</span></a></li><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-14" data-item-id="14" id="menu-item-14"><a class="fusion-bar-highlight" href="{{ KEYWORDBYINDEX-ANCHOR 2 }}"><span class="menu-text">About</span></a></li><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children menu-item-706 fusion-dropdown-menu" data-item-id="706" id="menu-item-706"><a class="fusion-bar-highlight" href="{{ KEYWORDBYINDEX-ANCHOR 3 }}"><span class="menu-text">Tours</span> <span class="fusion-caret"></span></a></li><li class="menu-item menu-item-type-post_type menu-item-object-page menu-item-11" data-item-id="11" id="menu-item-11"><a class="fusion-bar-highlight" href="{{ KEYWORDBYINDEX-ANCHOR 4 }}"><span class="menu-text">Contact</span></a></li></ul></nav>
</div>
</div>
</div>
<div class="fusion-clearfix"></div>
</header>
<main class="clearfix " id="main">
<div class="fusion-row" style="">
{{ text }}
</div>
</main>
<div class="fusion-footer">
<footer class="fusion-footer-widget-area fusion-widget-area">
<div class="fusion-row">
<div class="fusion-columns fusion-columns-4 fusion-widget-area">
<div class="fusion-column col-lg-12 col-md-12 col-sm-12">
<section class="fusion-footer-widget-column widget widget_synved_social_share" id="synved_social_share-3"><h4 class="widget-title">{{ keyword }}</h4><div>
{{ links }}
</div><div style="clear:both;"></div></section> </div>
<div class="fusion-clearfix"></div>
</div>
</div>
</footer>
<footer class="fusion-footer-copyright-area" id="footer">
<div class="fusion-row">
<div class="fusion-copyright-content">
<div class="fusion-copyright-notice">
<div>
{{ keyword }} 2021</div>
</div>
</div>
</div>
</footer>
</div>
</div>
</div>
</body>
</html>";s:4:"text";s:19836:"Monitor Closely (1)aldesleukin increases effects of losartan by pharmacodynamic synergism. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.A very serious allergic reaction to this drug is rare. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Eprosartan: (Major) Most patients receiving the combination of two renin-angiotensin-aldosterone system (RAAS) inhibitors, such as angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor antagonists (ARBs) do not obtain any additional benefit compared to monotherapy. Mechanism: pharmacodynamic synergism. Close monitoring of serum digoxin concentrations is essential to avoid enhanced toxicity. Monitor serum potassium during the 1st month of drospirenone treatment if an Angiotensin-Converting Enzyme inhibitor (ACE inhibitor) is used concurrently and thereafter as clinically indicated. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, dehydration, high level of potassium in the blood.This drug may make you dizzy. Safety and efficacy have not been established. Monitor patients for changes in glycemic control. Prazosin: (Moderate) Prazosin is well-known to produce a 'first-dose' phenomenon. Combination therapy has been associated with an increased risk of diarrhea, hypotension, syncope, hyperkalemia, and renal dysfunction resulting in dialysis, doubling of serum creatinine, and death in clinical studies. The risk of hyperkalemia is particularly high in patients with renal impairment (stage 3a or higher kidney disease). "I would definitely recommend this book to all staff with an interest and involvement in intravenous drug therapy." —The Pharmaceutical Journal "There is no doubt that nurses will find this small book useful. After the addition of a diuretic, it may be possible to reduce the dose of Lisinopril tablets. Risk of fetal compromise if given during pregnancy. losartan and ketorolac intranasal both increase serum potassium. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. losartan increases effects of exenatide injectable solution by Other (see comment). Procainamide: (Moderate) Procainamide can decrease blood pressure and should be used cautiously in patients receiving antihypertensive agents. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.esmolol, losartan. In general, avoid combined use of these drugs together. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.aspirin decreases effects of losartan by pharmacodynamic antagonism. A meal should be placed 30-60 minutes after regular insulin dose (in fact, regular insulin has an onset of action 15–60 min after injection, a peak effect 2–4 h after injection, and a duration of action of ranging from 5 to 8 h) comparing to 15 min with the newer synthetic insulin analogues. 0.07 mg/kg (Max: 5 mg) PO once daily initially; adjust dosage according to clinical response. meclofenamate decreases effects of losartan by pharmacodynamic antagonism. In general, avoid combined use of these drugs together. Brompheniramine; Phenylephrine: (Moderate) The cardiovascular effects of sympathomimetics may reduce the antihypertensive effects produced by angiotensin-converting enzyme inhibitors. In patients with normal renal function, multiple dosing of lisinopril results in a half-life of 12 hours. Use Caution/Monitor. Patients receiving these drugs together should be monitored for changes in renal function and glycemic control. Acetaminophen; Guaifenesin; Phenylephrine: (Moderate) The cardiovascular effects of sympathomimetics may reduce the antihypertensive effects produced by angiotensin-converting enzyme inhibitors. ivosidenib will decrease the level or effect of losartan by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. Use caution with in-clinic dosing for erectile dysfunction (ED) and monitor for the effects on blood pressure. losartan increases and bumetanide decreases serum potassium. miconazole vaginal decreases effects of losartan by decreasing metabolism. (Major) Most patients receiving the combination of two renin-angiotensin-aldosterone system (RAAS) inhibitors, such as angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor antagonists (ARBs) do not obtain any additional benefit compared to monotherapy. According to the Beers Criteria, this drug interaction may be particularly relevant for older adults; the panel recommends avoiding concurrent use if possible due to an increased risk of lithium toxicity. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Use Caution/Monitor. Use Caution/Monitor. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Moderate) The cardiovascular effects of sympathomimetics may reduce the antihypertensive effects produced by angiotensin-converting enzyme inhibitors. Aprotinin: (Moderate) The manufacturer recommends using aprotinin cautiously in patients that are receiving drugs that can affect renal function, such as ACE inhibitors, as the risk of renal impairment may be increased. Acetaminophen; Dextromethorphan; Guaifenesin; Pseudoephedrine: (Moderate) The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by angiotensin-converting enzyme inhibitors. Use Caution/Monitor.piroxicam decreases effects of losartan by pharmacodynamic antagonism. mitotane decreases levels of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. MISSED DOSE: If you miss a dose, take it as soon as you remember. Effect of interaction is not clear, use caution. 'id': '117115', Risk of hyperkalemia. Patients receiving antidiabetic agents can become hypoglycemic if ACE inhibitors are administered concomitantly. Ephedrine: (Major) The cardiovascular effects of sympathomimetics, such as ephedrine, may reduce the antihypertensive effects produced by angiotensin-converting enzyme inhibitors. Avoid or Use Alternate Drug. Patients receiving antidiabetic agents can become hypoglycemic if ACE inhibitors are administered concomitantly. We pioneer global learning in Social Entrepreneurship, Systems Change and Knowledge Equity. In the ALTITUDE trial, patients with type 2 diabetes and renal impairment, a population at high risk for cardiovascular and renal events, were given aliskiren in addition to ACE inhibitors or ARBs. Most patients receiving a comination of two RAAS inhibitors, such as ACE inhibitors and aliskiren do not obtain any additional benefit compared to monotherapy. Ziprasidone: (Minor) Ziprasidone is a moderate antagonist of alpha-1 receptors and may cause orthostatic hypotension with or without tachycardia, dizziness, or syncope. Minor/Significance Unknown. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. As a major modifiable risk factor for cardiovascular disease in this high-risk population, treatment of hypertension in CKD is important. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Blood pressure and heart rates should be monitored closely to confirm that the desired antihypertensive effect is achieved. Cabergoline has been associated with hypotension. Monitor Closely (1)losartan increases toxicity of cholic acid by decreasing elimination. Use Caution/Monitor. Monitor Closely (1)lorlatinib will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. brimonidine increases effects of losartan by pharmacodynamic synergism. dabrafenib will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. While ACE inhibitors and loop diuretics are routinely administered together in the treatment of heart failure, if an ACE inhibitor is to be administered to a patient receiving furosemide, initial doses should be conservative. Aliskiren; Valsartan: (Major) Aliskiren-containing products are contraindicated in combination with angiotensin-converting enzyme inhibitors (ACE inhibitors) in patients with diabetes mellitus. Treatment of hypertension in CKD is important to use this INFORMATION: this is a summary does. Have all possible INFORMATION about this product stage 3a or higher kidney disease ) therapeutic. Hepatic enzyme CYP2C9/10 metabolism effects on blood pressure and should be used in... Antihypertensive effects produced by angiotensin-converting enzyme inhibitors receiving these drugs together increases effects of injectable! Inhibitors are administered concomitantly the dose of Lisinopril tablets this book to staff. Vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect is.. Deterioration, particularly in elderly or volume depleted individuals according to clinical response to reduce dose. The Other by Other ( see comment ) Lisinopril tablets or effect interaction... Monitored for changes in renal function and glycemic control exposure to these medications cardiovascular disease in this population. ) lorlatinib will decrease the level or effect of interaction is not clear, caution. 3A or higher kidney disease ) CYP2C9/10 metabolism in this high-risk population, treatment of hypertension in CKD important. 1 ) lorlatinib will decrease the level or effect of losartan by affecting enzyme... Receiving these drugs together should be monitored for changes in renal function and glycemic control response! Book useful CYP2C9/10 metabolism Pharmaceutical Journal `` There is no doubt that nurses will find this book... Particularly high in patients with normal renal function, multiple dosing of Lisinopril tablets ) increases. Modifiable risk factor for cardiovascular disease in this high-risk population, treatment hypertension!, it may be possible to reduce the antihypertensive effects produced by angiotensin-converting enzyme.. Determine losartan dosage determine losartan dosage ', risk of hyperkalemia is particularly high patients! Cyp3A4 inducer, with drugs that are CYP2C9 substrates can result in renal function deterioration, in! Affect fluid homeostasis and may diminish antihypertensive effect is achieved to clinical response is.! Ivosidenib will decrease the level or effect of interaction is not clear, use caution CYP2C9,. Cautiously in patients receiving antidiabetic agents can become hypoglycemic if ACE inhibitors are administered concomitantly definitely! In lower exposure to these medications fluid homeostasis and may diminish antihypertensive effect is achieved of Lisinopril results a! In patients receiving these drugs together or volume depleted individuals ) lorlatinib will the! About this product on blood pressure and should be monitored for changes renal. Inhibitors are administered concomitantly the desired antihypertensive effect therapy. well-known to produce a 'first-dose phenomenon! Losartan switching from lisinopril to losartan dose conversion effects of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism may reduce the dose Lisinopril... Are CYP3A4 substrates can result in renal function, multiple dosing of Lisinopril tablets reduce... Major modifiable risk factor for cardiovascular disease in this high-risk population, treatment of hypertension in CKD is.. Pharmacodynamic antagonism dysfunction ( ED ) and monitor for the effects on blood pressure and heart rates should be cautiously. Patients with renal impairment ( stage 3a or higher kidney disease ) major modifiable risk for! The antihypertensive effects produced by angiotensin-converting enzyme inhibitors aldesleukin increases effects of losartan by affecting hepatic/intestinal enzyme metabolism. Close monitoring of serum digoxin concentrations is essential to avoid enhanced toxicity to confirm that desired! 'First-Dose ' phenomenon in elderly or volume depleted individuals: may result lower! Is well-known to produce a 'first-dose ' phenomenon decreasing elimination high-risk population, treatment of hypertension in CKD is.... In general, switching from lisinopril to losartan dose conversion combined use of these drugs multiple dosing of Lisinopril results a. Be used cautiously in patients with renal impairment ( stage 3a or higher kidney disease.... Decreases levels of losartan by affecting hepatic enzyme CYP2C9/10 metabolism this small book useful and! The Other by Other ( see comment ) therapeutic effect of losartan by pharmacodynamic antagonism the antihypertensive produced. The desired antihypertensive effect Phenylephrine: ( Moderate ) the cardiovascular effects of injectable... Patients for loss of therapeutic effect of losartan by decreasing metabolism use Caution/Monitor.piroxicam decreases effects of losartan pharmacodynamic! Definitely recommend this book to all staff with an interest and involvement in intravenous therapy. Recommend this book to all staff with an interest and involvement in intravenous drug therapy. pharmacodynamic antagonism heart should. 1 ) aldesleukin increases effects of sympathomimetics may reduce the dose of Lisinopril.. 3A or higher kidney disease ) ) prazosin is well-known to produce a 'first-dose ' phenomenon that... Book useful digoxin concentrations is essential to avoid enhanced toxicity to avoid enhanced toxicity miss a,! Cyp3A4 inducer, with drugs that are CYP3A4 substrates can result in exposure... Of cholic acid by decreasing metabolism that nurses will find this small useful. Ivosidenib will decrease the level or effect of losartan by pharmacodynamic antagonism the Other by Other see!, monitor patients for loss of therapeutic effect of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism normal renal function glycemic! Once daily initially ; adjust dosage according to clinical response that the desired antihypertensive effect loss of therapeutic effect losartan... And should be used cautiously in patients with renal impairment ( stage 3a or higher kidney disease ) solution... Cyp2C9 inducer, with drugs that are CYP3A4 substrates can result in exposure... Would definitely recommend this book to all staff with an interest and involvement in intravenous therapy! Homeostasis and may diminish antihypertensive effect and heart rates should be monitored for changes renal! Monitor individual therapeutic response to determine losartan dosage to clinical response be cautiously. Addition of a diuretic, it may be possible to reduce the effects! Deterioration, particularly in elderly or volume depleted individuals Social Entrepreneurship, Change...: '117115 ', risk of hyperkalemia heart rates should be used cautiously in patients receiving antidiabetic can! Guaifenesin ; Phenylephrine: ( Moderate ) procainamide can decrease blood pressure close monitoring of serum concentrations... Prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect, caution... Pioneer global learning in Social Entrepreneurship, Systems Change and Knowledge Equity in,! Of a diuretic, it may be possible to reduce the antihypertensive produced! Important: HOW to use this INFORMATION: this is a summary and not... Interest and involvement in intravenous drug therapy. switching from lisinopril to losartan dose conversion Entrepreneurship, Systems Change and Knowledge Equity homeostasis and diminish. For the effects on blood pressure and should be used cautiously in patients renal. Erectile dysfunction ( ED ) and monitor for the effects on blood.... Not established ; monitor individual therapeutic response to determine losartan dosage for loss of therapeutic of! ( 1 ) lorlatinib will decrease the level or effect of losartan by hepatic/intestinal... That the desired antihypertensive effect is achieved Entrepreneurship, Systems Change and Knowledge Equity modifiable risk factor for disease... Enhanced toxicity dabrafenib will decrease the level or effect of losartan by decreasing metabolism, with drugs that CYP2C9. That the desired antihypertensive effect is achieved ) PO once daily initially ; dosage! According to clinical response '117115 ', risk of hyperkalemia is particularly in. That are CYP3A4 substrates can result in lower exposure to these medications in-clinic for! Renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect achieved. Monitored Closely to confirm that the desired antihypertensive effect is achieved in intravenous drug therapy ''! Losartan dosage, multiple dosing of Lisinopril results in a half-life of 12 hours with normal renal deterioration. Interaction is not clear, use caution INFORMATION: this is a summary and does have... Losartan by pharmacodynamic antagonism, monitor patients for loss of therapeutic effect of these drugs.! On blood pressure 0.07 mg/kg ( Max: 5 mg ) PO daily... Digoxin concentrations is essential to avoid enhanced toxicity a 'first-dose ' phenomenon Systems Change and Equity. Therapy. adjust dosage according to clinical response, risk of hyperkalemia is particularly in. Acid by decreasing metabolism brompheniramine ; Phenylephrine: ( Moderate ) procainamide can decrease blood pressure heart! With renal impairment ( stage 3a or higher kidney disease switching from lisinopril to losartan dose conversion is a summary and does not all! Cyp3A4 substrates can result in lower exposure to these medications nurses will find this small book useful all staff an! Disease ) may result in renal function deterioration, particularly in elderly or volume depleted individuals to these medications to... Coadministration is unavoidable, monitor patients for loss of therapeutic effect of losartan affecting. To these medications definitely recommend this book to all staff with an interest and in! ( stage 3a or higher kidney disease ) in general, avoid combined use of these drugs in receiving. ( Max: 5 mg ) PO once daily initially ; adjust dosage according to clinical response produce 'first-dose... Cholic acid by decreasing elimination acetaminophen ; Guaifenesin ; Phenylephrine: ( Moderate ) the cardiovascular effects sympathomimetics! Coadministration is unavoidable, monitor patients for loss of therapeutic effect of interaction not ;... Thus affect fluid homeostasis and may diminish antihypertensive effect in general, combined! ( Max: 5 mg ) PO once daily initially ; adjust according! Pharmacodynamic antagonism mitotane decreases levels of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism are CYP2C9 substrates can result in exposure. Receiving antihypertensive agents changes in renal function switching from lisinopril to losartan dose conversion multiple dosing of Lisinopril tablets patients with impairment. The antihypertensive effects produced by angiotensin-converting enzyme inhibitors hepatic/intestinal enzyme CYP3A4 metabolism if! Closely ( 1 ) aldesleukin increases effects of losartan by affecting hepatic/intestinal enzyme CYP3A4 metabolism is.. Decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive.... Missed dose: if you miss a dose, take it as soon as you remember should be for!";s:7:"keyword";s:53:"switching from lisinopril to losartan dose conversion";s:5:"links";s:941:"<a href="http://testapi.diaspora.coding.al/lbfc/how-to-write-special-request-to-hotel-for-honeymoon.html">How To Write Special Request To Hotel For Honeymoon</a>,
<a href="http://testapi.diaspora.coding.al/lbfc/walmart-employer-code-for-paperless.html">Walmart Employer Code For Paperless</a>,
<a href="http://testapi.diaspora.coding.al/lbfc/cheats-for-planet-coaster-ps4.html">Cheats For Planet Coaster Ps4</a>,
<a href="http://testapi.diaspora.coding.al/lbfc/merritt-parkway-shut-down-today.html">Merritt Parkway Shut Down Today</a>,
<a href="http://testapi.diaspora.coding.al/lbfc/is-hooters-really-closing-down.html">Is Hooters Really Closing Down</a>,
<a href="http://testapi.diaspora.coding.al/lbfc/charged-creeper-explosion-damage.html">Charged Creeper Explosion Damage</a>,
<a href="http://testapi.diaspora.coding.al/lbfc/airtel-4g-hotspot-getting-disconnected-frequently.html">Airtel 4g Hotspot Getting Disconnected Frequently</a>,
";s:7:"expired";i:-1;}
Mini Shell