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Guidance on the Application of the CLP Criteria (update of Part 3 - Health Hazards relating to specific concentration limits (SCLs) for 4 hazard classes, and the inclusion of a new Annex) Guidance on the Application of the CLP Criteria. The 7(a) loan program is the SBA's primary program for providing financial assistance to small businesses. Guidance on Information Requirements and Chemical Safety Assessment (ECHA), Chapter R.7a: Endpoint specific guidance OECD (2014). Chapter R.7a: Endpoint specific guidance 3Rs implications None to report European Directorate for the Quality of Medicines & HealthCare (EDQM) European Pharmacopeia Monographs and General Chapters 3Rs implications Revision of 49 monographs to remove the test for abnormal toxicity; including 36 monographs on Chapter R.7a : endpoint specific guidance Latest edition. ECHA-14-G-03-EN. It is part of a series of guidance documents that are aimed to help all Publication metadata. In addition, ECHA has published updates to three of its existing guidance on nanomaterials, which are the appendices for nanomaterials to Chapter R.7a, R.7b and R.7c of the Guidance on IR&CSA (Endpoint specific guidance). 203: Integrated Approach on Testing and Assessment for Skin Corrosion and Irritation : Exposure scenario building and environmental release estimation for the waste life stage REACH Annex XIII. 5. International Union of Pure and Applied Chemistry (IUPAC) (1976), Physicochemical Measurements: guidance does not address endpoints for drugs to prevent or decrease the incidence of cancer. Preface . Chapter R.7a Endpoint specific guidance; Section R.7.4, Acute Toxicity . Guidance document No. Chapter R.7a Endpoint specific guidance. This guidance is a revision of the final guidance of the same title that published in May 2007. R. Emter, G. Ellis, A. NatschPerformance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. This document describes the information requirements under REACH with regard to substance properties, exposure, uses and risk management measures, and the chemical safety assessment. This document describes the information requirements under REACH with regard to substance properties, exposure, uses and risk management measures, and the chemical safety assessment. registrations . The terms and conditions, like the guaranty percentage and loan amount, may vary by … 4. Chapter R.7a: Endpoint specific guidance Version 2.4 – February 2014 3 . The latest draft update to the information requirements and chemical safety assessment (IR&CSA) guidance involves an amendment to Chapter R.7a (endpoint specific guidance), notably sections 7.3 (skin and respiratory sensitisation) and 7.5 (repeated dose toxicity). European Chemicals Agency (2008), Guidance on information requirements and chemical safety assessment, Chapter R.7a: Endpoint specific guidance, Guidance for the implementation of REACH, European Chemicals Agency. European Chemicals Agency (2017). ECHAGuidance on Information Requirements and Chemical Safety Assessment Chapter R.7a: Endpoint Specific Guidance (2017) Google Scholar. Report no. Update of the complete section, particularly to address a data waiving option for acute oral toxicity by prediction from repeated-dose toxicity for the 2018 > 10 t.p.a. Emter et al., 2010. 12 European Commission (2007). 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