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Of course, not all dogs develop side effects, but the possibility is there, so if you decide to put your older dog on Proin® watch out for the symptoms described above. Side Effects of Doxycycline for Dogs Dogs generally tolerate doxycycline well, but it is always a good idea to understand the possible side effects of a drug before you give your dog a new medication. Natural Remedies for Old Dog Urinary Incontinence Additional side effects can be found on the product info. Urinary tract infections and/or stones can also cause urinary incontinence in dogs. Steroids are synthetic hormones that are used to treat several health issues in dogs. Many dogs need only three to five treatments to restore normal function. DES may be used with the alpha-agonist phenylpropanolamine. This is a popular natural treatment for difficult to treat urinary incontinence in dogs. Adjustments in medication can minimize the side effects in most dogs. Dogs and Cats. Estrogens may also be used for USMI and these hormones are thought to sensitize the α1-AR to the norepinephrine and indirectly result in an improvement in the closure pressure. Side effects in dogs include restlessness, anxiety, hypertension and tachycardia. For treatment of nerve pain, the dosage varies between 11 – 22 mg/lb body weight, administered twice daily or as per the vet’s instructions. It contains a natural estrogen hormone called Estriadol. Phenylpropanolamine Side Effects. Give your dog medication. This class of drugs is not recommended in patients with cardiac disease or hypertension. Uses of Diethylstilbestrol for Dogs; Diethylstilbestrol (DES) is prescribed for the treatment of hormonal responsive urinary incontinence in the spayed female dog. In 2011 a new hormone replacement drug was launched onto the market and is used to treat incontinence in female dogs. SIDE EFFECTS NOTICED IN DOGS The most common side effects that are seen when giving phenylpropanolamine to dogs are: Excessive energy and restlessness; Increased blood pressure; Increased heart rate; Loss of appetite; As with other drugs, there is the chance that your pet will be allergic to this medicine. There are other drugs that also can be used in place of DES. Adjustments are made to the dosage based on how the dog reacts to the treatment, and also depending on whether the pet is on other reactive medication. If you are interested in this treatment, a holistic veterinarian can tell you more. Some steroidal medications can also cause urinary incontinence in dogs. Unfortunately, one of the side effects … Follow your veterinarian's suggestions for treatment. DES is used primarily to treat urinary incontinence in spayed females. DES usually is effective for this purpose and the risk of side effects is relatively low due to the small dose. Be aware that these medications can have side effects. Estrogens increase urethral tone and help to prevent leaking or dribbling of urine. However, DES may be the better choice in those pets that cannot tolerate phenylpropanolamine or ephedrine. It works to stimulate the nerves responsible for urinary control. Another potential side effect is irritability in the dog taking the medication. Dogs suffering from urinary incontinence typically have great success when treated with the proper medication. Possible serious side effects…. In 2012, Merck Animal Health introduced a medication for female canine urinary incontinence called Incurin. PPA … In most cases, if spay incontinence is diagnosed, your veterinarian will first prescribe either estrogen or alpha agonist phenylpropanolamine (PPA). 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